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Review
. 2020 Mar;476(3):353-365.
doi: 10.1007/s00428-019-02724-4. Epub 2019 Dec 13.

Thirty years of Epstein-Barr virus-associated gastric carcinoma

Masashi Fukayama  1   2 , Hiroyuki Abe  3 , Akiko Kunita  3 , Aya Shinozaki-Ushiku  3 , Keisuke Matsusaka  4   5 , Tetsuo Ushiku  3 , Atsushi Kaneda  5
Affiliations
Review

Thirty years of Epstein-Barr virus-associated gastric carcinoma

Masashi Fukayama et al. Virchows Arch. 2020 Mar.

Abstract

Thirty years have passed since a possible association of Epstein-Barr virus (EBV) with gastric carcinoma was reported. We now know EBV-associated gastric carcinoma to be a specific subtype of gastric carcinoma. Global epigenetic methylation and counteraction of the antitumour microenvironment are two major characteristics of this subtype of gastric carcinoma. Recent development of therapeutic modalities for gastric carcinoma, such as endoscopic mucosal dissection and immune checkpoint inhibitor therapy, has made the presence of EBV infection a biomarker for the treatment of gastric carcinoma. This review presents a portrait of EBV-associated gastric carcinoma from initiation to maturity that we define as the 'gastritis-infection-cancer sequence', followed by its molecular abnormalities and interactions with immune checkpoint molecules and the microenvironment. EBV non-coding RNAs (microRNA and circular RNA) and exosomes derived from EBV-infected cells that were previously behind the scenes are now recognized for their roles in EBV-associated gastric carcinoma. The virus utilizes cellular machinery skilfully to control infected cells and their microenvironment. We should thus strive to understand virus-host interactions more fully in the following years to overcome this virus-driven subtype of gastric carcinoma.

Keywords: DNA methylation; Epstein-Barr virus; Exosome; Gastric carcinoma; Gastritis; Immune evasion; Infection; MicroRNA.

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References

    1. Epstein MA, Achong BG, Barr YM (1964) Virus particles in cultured lymphoblasts from Burkitt’s lymphoma. Lancet 15:702–703. https://doi.org/10.1016/s0140-6736(64)91524-7 - DOI
    1. Young LS, Yap LF, Murray PG (2015) Epstein-Barr virus: more than 50 years old and still providing surprises. Nature Rev Cancer 16:789–802. https://doi.org/10.1038/nrc.2016.92 - DOI
    1. Burke AP, Yen TS, Shekitka KM, Sobin LH (1990) Lymphoepithelial carcinoma of the stomach with Epstein-Barr virus demonstrated by polymerase chain reaction. Mod Pathol 3:377–380 - PubMed
    1. Howe JG, Steitz JA (1986) Localization of Epstein-Barr virus-encoded small RNAs by in situ hybridization. Proc Natl Acad Sci U S A 83:9006–9010 - DOI
    1. Wu TC, Mann RB, Charache P, Hayward SD, Staal S, Lambe BC, Ambinder RF (1990) Detection of EBV gene expression in reed-Sternberg cells of Hodgkin's disease. Int J Cancer 46:801–804 - DOI

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