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Review
. 2020 Mar;14(2):237-243.
doi: 10.1111/irv.12706. Epub 2019 Dec 13.

Meeting report and review: Immunological assays and correlates of protection for next-generation influenza vaccines

Florian Krammer  1 , Jerry P Weir  2 , Othmar Engelhardt  3 , Jacqueline M Katz  4 , Rebecca Jane Cox  5
Affiliations
Review

Meeting report and review: Immunological assays and correlates of protection for next-generation influenza vaccines

Florian Krammer et al. Influenza Other Respir Viruses. 2020 Mar.

Abstract

Background: This report summarizes the discussions and conclusions from the "Immunological Assays and Correlates of Protection for Next-Generation Influenza Vaccines" meeting which took place in Siena, Italy, from March 31, 2019, to April 2, 2019.

Conclusions: Furthermore, we review current correlates of protection against influenza virus infection and disease and their usefulness for the development of next generation broadly protective and universal influenza virus vaccines.

Keywords: CD4; CD8; HI; MN; NI; correlates of protection; influenza; influenza vaccine; mucosal immunity; stalk antibodies.

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References

    1. Hobson D, Curry RL, Beare AS, Ward‐Gardner A. The role of serum haemagglutination‐inhibiting antibody in protection against challenge infection with influenza A2 and B viruses. J Hyg (Lond). 1972;70(4):767‐777. - PMC - PubMed
    1. Coudeville L, Bailleux F, Riche B, Megas F, Andre P, Ecochard R. Relationship between haemagglutination‐inhibiting antibody titres and clinical protection against influenza: development and application of a bayesian random‐effects model. BMC Med Res Methodol. 2010;10:18. - PMC - PubMed
    1. de Jong JC, Palache AM, Beyer WE, Rimmelzwaan GF, Boon AC, Osterhaus AD. Haemagglutination‐inhibiting antibody to influenza virus. Dev Biol (Basel). 2003;115:63‐73. - PubMed
    1. McMichael AJ, Gotch FM, Noble GR, Beare PA. Cytotoxic T‐cell immunity to influenza. N Engl J Med. 1983;309(1):13‐17. - PubMed
    1. Hayward AC, Wang L, Goonetilleke N, et al. Cell‐mediated protection against seasonal and pandemic influenza. Results of the Flu Watch Cohort Study. Am J Respir Crit Care Med. 2015;191(12):1422‐1431. - PMC - PubMed

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