Clinicopathologic analysis of intraductal papillary neoplasm of bile duct: Korean multicenter cohort study

Jae Ri Kim¹, Kee-Taek Jang², Jin-Young Jang³, Kyungbun Lee⁴, Jung Hoon Kim⁵, Haeryoung Kim⁶, Sun-Whe Kim¹, Wooil Kwon¹, Dong Wook Choi⁷, JinSeok Heo⁷, In Woong Han⁷, Shin Hwang⁸, Wan-Joon Kim⁸, Seung-Mo Hong⁹, Dong-Sik Kim¹⁰, Young-Dong Yu¹⁰, Joo Young Kim¹¹, Yang Won Nah¹², Hyung Woo Park¹², Hye-Jeong Choi¹³, Ho-Seong Han¹⁴, Yoo-Seok Yoon¹⁴, Sang Jae Park¹⁵, Eun Kyung Hong¹⁶, Hyung Il Seo¹⁷, Do Youn Park¹⁸, Koo Jeong Kang¹⁹, Yu Na Kang²⁰, Hee Chul Yu²¹, Woo Sung Moon²², Chang-Sup Lim²³, Jeong Mo Bae²⁴, Sungho Jo²⁵, Wonae Lee²⁶, Young Hun Roh²⁷, Jin Sook Jeong²⁸, Chi-Young Jeong²⁹, Jong Sil Lee³⁰, In-Sang Song³¹, Kyung-Hee Kim³², Ho Gak Kim³³, Chang Ho Cho³⁴, Sun-Hyung Joo³⁵, Kyu Yeoun Won³⁶, Hong Jin Kim³⁷, Joon Hyuk Choi³⁸, Chong-Woo Chu³⁹, Jung Hee Lee⁴⁰, Il Young Park⁴¹, Heejeong Lee⁴², Seung Eun Lee⁴³, Hee Sung Kim⁴⁴, Hyeon Kook Lee⁴⁵, Min-Sun Cho⁴⁶, Hongbeom Kim⁴⁷, Kang Min Han⁴⁸

Affiliations

¹ Dept. of Surgery, Seoul National University College of Medicine (Seoul National University Hospital), South Korea.
² Dept. of Pathology, Sungkyunkwan University School of Medicine (Samsung Medical Center), South Korea.
³ Dept. of Surgery, Seoul National University College of Medicine (Seoul National University Hospital), South Korea. Electronic address: jangjy4@gmail.com.
⁴ Dept. of Pathology, Seoul National University College of Medicine (Seoul National University Hospital), South Korea.
⁵ Dept. of Radiology, Seoul National University College of Medicine (Seoul National University Hospital), South Korea.
⁶ Dept. of Pathology, Seoul National University College of Medicine (Seoul National University Hospital), South Korea; Dept. of Pathology, Seoul National University College of Medicine (Seoul National University Bundang Hospital), South Korea.
⁷ Dept. of Surgery, Sungkyunkwan University School of Medicine (Samsung Medical Center), South Korea.
⁸ Dept. of Surgery, University of Ulsan College of Medicine (Asan Medical Center), South Korea.
⁹ Dept. of Pathology, University of Ulsan College of Medicine (Asan Medical Center), South Korea.
¹⁰ Dept. of Surgery, Korea University College of Medicine, South Korea.
¹¹ Dept. of Pathology, Korea University College of Medicine, South Korea.
¹² Dept. of Surgery, University of Ulsan College of Medicine (Ulsan University Hospital), South Korea.
¹³ Dept. of Pathology, University of Ulsan College of Medicine (Ulsan University Hospital), South Korea.
¹⁴ Dept. of Surgery, Seoul National University College of Medicine (Seoul National University Bundang Hospital), South Korea.
¹⁵ Dept. of Surgery, National Cancer Center, South Korea.
¹⁶ Dept. of Pathology, National Cancer Center, South Korea.
¹⁷ Dept. of Surgery, Pusan National University School of Medicine (Pusan National University Hospital), South Korea.
¹⁸ Dept. of Pathology, Pusan National University School of Medicine (Pusan National University Hospital), South Korea.
¹⁹ Dept. of Surgery, Keimyung University School of Medicine, South Korea.
²⁰ Dept. of Pathology, Keimyung University School of Medicine, South Korea.
²¹ Dept. of Surgery, Chonbuk National University Medical School, South Korea.
²² Dept. of Pathology, Chonbuk National University Medical School, South Korea.
²³ Dept. of Surgery, Seoul National University College of Medicine (Boramae Medical Center), South Korea.
²⁴ Dept. of Pathology, Seoul National University College of Medicine (Boramae Medical Center), South Korea.
²⁵ Dept. of Surgery, Dankook University College of Medicine, South Korea.
²⁶ Dept. of Pathology, Dankook University College of Medicine, South Korea.
²⁷ Dept. of Surgery, Dong-A University College of Medicine, South Korea.
²⁸ Dept. of Pathology, Dong-A University College of Medicine, South Korea.
²⁹ Dept. of Surgery, Gyeongsang National University Postgraduate School of Medicine, South Korea.
³⁰ Dept. of Pathology, Gyeongsang National University Postgraduate School of Medicine, South Korea.
³¹ Dept. of Surgery, Chungnam National University School of Medicine, South Korea.
³² Dept. of Pathology, Chungnam National University School of Medicine, South Korea.
³³ Dept. of Surgery, Daegu Catholic University School of Medicine, South Korea.
³⁴ Dept. of Pathology, Daegu Catholic University School of Medicine, South Korea.
³⁵ Dept. of Surgery, Kyung Hee University School of Medicine, South Korea.
³⁶ Dept. of Pathology, Kyung Hee University School of Medicine, South Korea.
³⁷ Dept. of Surgery, Yeungnam University College of Medicine, South Korea.
³⁸ Dept. of Pathology, Yeungnam University College of Medicine, South Korea.
³⁹ Dept. of Surgery, Pusan National University School of Medicine (Pusan National University Yangsan Hospital), South Korea.
⁴⁰ Dept. of Pathology, Pusan National University School of Medicine (Pusan National University Yangsan Hospital), South Korea.
⁴¹ Dept. of Surgery, Catholic University College of Medicine, South Korea.
⁴² Dept. of Pathology, Catholic University College of Medicine, South Korea.
⁴³ Dept. of Surgery, Chung-Ang University College of Medicine, South Korea.
⁴⁴ Dept. of Pathology, Chung-Ang University College of Medicine, South Korea.
⁴⁵ Dept. of Surgery, Ewha Womans University School of Medicine, South Korea.
⁴⁶ Dept. of Pathology, Ewha Womans University School of Medicine, South Korea.
⁴⁷ Dept. of Surgery, Seoul National University College of Medicine (Seoul National University Hospital), South Korea; Dept. of Surgery, Dongguk University College of Medicine (Dongguk University Ilsan Hospital), South Korea.
⁴⁸ Dept. of Pathology, Dongguk University College of Medicine (Dongguk University Ilsan Hospital), South Korea.

PMID: 31837945
DOI: 10.1016/j.hpb.2019.11.007

Free article

Multicenter Study

Clinicopathologic analysis of intraductal papillary neoplasm of bile duct: Korean multicenter cohort study

Jae Ri Kim et al. HPB (Oxford). 2020 Aug.

Free article

. 2020 Aug;22(8):1139-1148.

doi: 10.1016/j.hpb.2019.11.007. Epub 2019 Dec 11.

Authors

Affiliations

¹ Dept. of Surgery, Seoul National University College of Medicine (Seoul National University Hospital), South Korea.
² Dept. of Pathology, Sungkyunkwan University School of Medicine (Samsung Medical Center), South Korea.
³ Dept. of Surgery, Seoul National University College of Medicine (Seoul National University Hospital), South Korea. Electronic address: jangjy4@gmail.com.
⁴ Dept. of Pathology, Seoul National University College of Medicine (Seoul National University Hospital), South Korea.
⁵ Dept. of Radiology, Seoul National University College of Medicine (Seoul National University Hospital), South Korea.
⁶ Dept. of Pathology, Seoul National University College of Medicine (Seoul National University Hospital), South Korea; Dept. of Pathology, Seoul National University College of Medicine (Seoul National University Bundang Hospital), South Korea.
⁷ Dept. of Surgery, Sungkyunkwan University School of Medicine (Samsung Medical Center), South Korea.
⁸ Dept. of Surgery, University of Ulsan College of Medicine (Asan Medical Center), South Korea.
⁹ Dept. of Pathology, University of Ulsan College of Medicine (Asan Medical Center), South Korea.
¹⁰ Dept. of Surgery, Korea University College of Medicine, South Korea.
¹¹ Dept. of Pathology, Korea University College of Medicine, South Korea.
¹² Dept. of Surgery, University of Ulsan College of Medicine (Ulsan University Hospital), South Korea.
¹³ Dept. of Pathology, University of Ulsan College of Medicine (Ulsan University Hospital), South Korea.
¹⁴ Dept. of Surgery, Seoul National University College of Medicine (Seoul National University Bundang Hospital), South Korea.
¹⁵ Dept. of Surgery, National Cancer Center, South Korea.
¹⁶ Dept. of Pathology, National Cancer Center, South Korea.
¹⁷ Dept. of Surgery, Pusan National University School of Medicine (Pusan National University Hospital), South Korea.
¹⁸ Dept. of Pathology, Pusan National University School of Medicine (Pusan National University Hospital), South Korea.
¹⁹ Dept. of Surgery, Keimyung University School of Medicine, South Korea.
²⁰ Dept. of Pathology, Keimyung University School of Medicine, South Korea.
²¹ Dept. of Surgery, Chonbuk National University Medical School, South Korea.
²² Dept. of Pathology, Chonbuk National University Medical School, South Korea.
²³ Dept. of Surgery, Seoul National University College of Medicine (Boramae Medical Center), South Korea.
²⁴ Dept. of Pathology, Seoul National University College of Medicine (Boramae Medical Center), South Korea.
²⁵ Dept. of Surgery, Dankook University College of Medicine, South Korea.
²⁶ Dept. of Pathology, Dankook University College of Medicine, South Korea.
²⁷ Dept. of Surgery, Dong-A University College of Medicine, South Korea.
²⁸ Dept. of Pathology, Dong-A University College of Medicine, South Korea.
²⁹ Dept. of Surgery, Gyeongsang National University Postgraduate School of Medicine, South Korea.
³⁰ Dept. of Pathology, Gyeongsang National University Postgraduate School of Medicine, South Korea.
³¹ Dept. of Surgery, Chungnam National University School of Medicine, South Korea.
³² Dept. of Pathology, Chungnam National University School of Medicine, South Korea.
³³ Dept. of Surgery, Daegu Catholic University School of Medicine, South Korea.
³⁴ Dept. of Pathology, Daegu Catholic University School of Medicine, South Korea.
³⁵ Dept. of Surgery, Kyung Hee University School of Medicine, South Korea.
³⁶ Dept. of Pathology, Kyung Hee University School of Medicine, South Korea.
³⁷ Dept. of Surgery, Yeungnam University College of Medicine, South Korea.
³⁸ Dept. of Pathology, Yeungnam University College of Medicine, South Korea.
³⁹ Dept. of Surgery, Pusan National University School of Medicine (Pusan National University Yangsan Hospital), South Korea.
⁴⁰ Dept. of Pathology, Pusan National University School of Medicine (Pusan National University Yangsan Hospital), South Korea.
⁴¹ Dept. of Surgery, Catholic University College of Medicine, South Korea.
⁴² Dept. of Pathology, Catholic University College of Medicine, South Korea.
⁴³ Dept. of Surgery, Chung-Ang University College of Medicine, South Korea.
⁴⁴ Dept. of Pathology, Chung-Ang University College of Medicine, South Korea.
⁴⁵ Dept. of Surgery, Ewha Womans University School of Medicine, South Korea.
⁴⁶ Dept. of Pathology, Ewha Womans University School of Medicine, South Korea.
⁴⁷ Dept. of Surgery, Seoul National University College of Medicine (Seoul National University Hospital), South Korea; Dept. of Surgery, Dongguk University College of Medicine (Dongguk University Ilsan Hospital), South Korea.
⁴⁸ Dept. of Pathology, Dongguk University College of Medicine (Dongguk University Ilsan Hospital), South Korea.

PMID: 31837945
DOI: 10.1016/j.hpb.2019.11.007

Abstract

Background: IPNB is very rare disease and most previous studies on IPNB were case series with a small number due to low incidence. The aim of this study is to validate previously known clinicopathologic features of intraductal papillary neoplasm of bile duct (IPNB) based on the first largest multicenter cohort.

Methods: Among 587 patients previously diagnosed with IPNB and similar diseases from each center in Korea, 387 were included in this study after central pathologic review. We also reviewed all preoperative image data.

Results: Of 387 patients, 176 (45.5%) had invasive carcinoma and 21 (6.0%) lymph node metastasis. The 5-year overall survival was 80.9% for all patients, 88.8% for IPNB with mucosal dysplasia, and 70.5% for IPNB with invasive carcinoma. According to the "Jang & Kim's modified anatomical classification," 265 (68.5%) were intrahepatic, 103 (26.6%) extrahepatic, and 16 (4.1%) diffuse type. Multivariate analysis revealed that tumor invasiveness was a unique predictor for survival analysis. (p = 0.047 [hazard ratio = 2.116, 95% confidence interval 1.010-4.433]).

Conclusions: This is the first Korean multicenter study on IPNB through central pathologic and radiologic review process. Although IPNB showed good long-term prognosis, relatively aggressive features were also found in invasive carcinoma and extrahepatic/diffuse type.

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Clinicopathologic analysis of intraductal papillary neoplasm of bile duct: Korean multicenter cohort study

Affiliations

Clinicopathologic analysis of intraductal papillary neoplasm of bile duct: Korean multicenter cohort study

Authors

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Abstract

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LinkOut - more resources

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Medical