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. 2020 Mar 5;30(3):111-115.
doi: 10.2188/jea.JE20190249. Epub 2019 Dec 14.

Japanese Legacy Cohorts: Six-Prefecture Cohort Study (Hirayama Cohort Study)

Suminori Akiba  1   2 , Yoshihide Kinjo  3
Affiliations

Japanese Legacy Cohorts: Six-Prefecture Cohort Study (Hirayama Cohort Study)

Suminori Akiba et al. J Epidemiol. .

Abstract

Late Dr Takeshi Hirayama and his colleagues conducted a mortality follow-up of a large-scale cohort in six prefectures in Japan. This study is called the six-prefecture cohort study or Hirayama Cohort Study. The study subjects were residents aged 40 years or older at the baseline survey in 1965, which covered 94.8% of residents identified in the study area by the National Census conducted on October 1, 1965. The mortality of 264,118 cohort members was followed until the end of 1982. One of the most important findings made by this study was an association between second-hand smoke exposure and lung cancer. This finding is the origin of the worldwide spread of smoking ban in indoor public venues and workplaces. Other major findings obtained from the study are also briefly described in this article.

Keywords: cancer epidemiology; cohort study; smoking.

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Figures

Figure 1.
Figure 1.
Figure 2.
Figure 2.. Geographical location of the prefectures sampled in Japan.
See this image and copyright information in PMC

References

    1. Hirayama T. Life-style and mortality: A large-scale census-based cohort study in Japan. In: Heidelberg JW, series editor. Contributions to Epidemiology and Biostatistics. Vol. 6. Karger; 1990.
    1. Doll R, Peto R. Mortality in relation to smoking: 20 years’ observations on male British doctors. BMJ. 1976;ii:1525–1536. 10.1136/bmj.2.6051.1525 - DOI - PMC - PubMed
    1. Hammond EC, Horn D. Smoking and death rates; report on forty-four months of follow-up of 187,783 men. I. Total mortality. J Am Med Assoc. 1958;166:1159–1172. 10.1001/jama.1958.02990100047009 - DOI - PubMed
    1. Kahn HA. The Dorn study of smoking and mortality among U.S. veterans: report on eight and one-half years of observation. Natl Cancer Inst Monogr. 1966;19:1–125. - PubMed
    1. Weir JM, Dunn JE Jr. Smoking and mortality: a prospective study. Cancer. 1970;25:105–112. 10.1002/1097-0142(197001)25:1<105::AID-CNCR2820250115>3.0.CO;2-Z - DOI - PubMed

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