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. 2019 Dec 4:11:2515841419892056.
doi: 10.1177/2515841419892056. eCollection 2019 Jan-Dec.

Comparison of optical coherence tomography angiography results of adult patients with Familial Mediterranean fever and healthy individuals

Emine Esra Karaca  1 , Dilay Ozek  1 , Ahmet Omma  2 , Ozlem Evren Kemer  1
Affiliations

Comparison of optical coherence tomography angiography results of adult patients with Familial Mediterranean fever and healthy individuals

Emine Esra Karaca et al. Ther Adv Ophthalmol. .

Abstract

Purpose: The aim of this study is to assess the macular ultrastructure measuring by optical coherence tomography angiography in adult patients with Familial Mediterranean fever.

Methods: Participants were 62 Familial Mediterranean fever patients and 54 healthy individuals in control group with similar age and sex. The superficial and deep vascular plexus structures covering the central fovea in an area of 6 mm × 6 mm were measured using AngioVue images taken with optical coherence tomography angiography. Vasculature structure, foveal avascular zone, acircularity index of foveal avascular zone (the ratio of the perimeter of foveal avascular zone and the perimeter of a circle with the equal area), and superficial and deep retinal plexus densities were measured.

Results: The inferior deep vascular density was measured: 49.17% ± 8.59% in Familial Mediterranean fever patients, 55.56% ± 5.92% in the control group. The deep inferior-hemi vascular density was measured: 48.59% ± 10.34% in Familial Mediterranean fever patients, 56.54% ± 8.05% in the control group. Deep inferior and deep inferior-hemi vascular density was significantly reduced in Familial Mediterranean fever patients compared with healthy controls (p = 0.04 and p = 0.03, respectively).

Conclusion: The vascular abnormalities in optical coherence tomography angiography show subclinical signs of microangiopathy in Familial Mediterranean fever patients. This observation, which can be obtained only through optical coherence tomography angiography, may be an ocular hallmark for Familial Mediterranean fever disease.

Keywords: Familial Mediterranean fever; angiography; macula; optical coherence tomography angiography; vessel density.

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Conflict of interest statement

Conflict of interest statement: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Optic coherence angiography image of superficial capillary plexus in FMF patient. FMF: Familial Mediterranean fever.
Figure 2.
Figure 2.
Optic coherence angiography density assessment tool for superficial capillary plexus in FMF patient. FMF: Familial Mediterranean fever.
Figure 3.
Figure 3.
FAZ assessment tools of optical coherence tomography angiography in FMF patient. FAZ area (mm2) in whole retina, FAZ perimeter (mm), acircularity index of the FAZ, and foveal density (FD-300) are demonstrated. FAZ: foveal avascular zone; FMF: Familial Mediterranean fever.
See this image and copyright information in PMC

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