Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jan-Dec:24:2515690X19891952.
doi: 10.1177/2515690X19891952.

Evaluation of In Vivo Antidiarrheal Activities of Hydroalcoholic Leaf Extract of Dodonaea viscosa L.(Sapindaceae) in Swiss Albino Mice

Jemal Abdela  1
Affiliations

Evaluation of In Vivo Antidiarrheal Activities of Hydroalcoholic Leaf Extract of Dodonaea viscosa L.(Sapindaceae) in Swiss Albino Mice

Jemal Abdela. J Evid Based Integr Med. 2019 Jan-Dec.

Abstract

Traditionally people used Dodonaea viscosa for the treatment of various ailments, including diarrhea. Therefore, this study was aimed to evaluate the antidiarrheal activity of the 80% methanolic leaf extract of D viscosa against castor oil-induced diarrhea in mice models. Different doses of 80% methanolic leaf extract of D viscosa (100, 200, and 400 mg/kg) were evaluated for their antidiarrheal activities using castor oil-induced diarrhea, gastrointestinal transit, and enteropooling models in Swiss albino mice. At all test doses, the plant extract showed significant (P < .05) inhibition in the frequency of defecation of wet feces and total fecal output as compared to the control group. Similarly, at all dose ranges used the plant extract demonstrated significant (P < .05) reduction in an intraluminal fluid accumulation as compared to the untreated group. Besides, at higher doses, the plant extract also indicated significant (P < .05) antimotility activity in comparison with the control. In conclusion, these findings illustrated that the 80% methanolic leaf extract of D viscosa supported the traditional claim of antidiarrheal activity of the plant though further investigations are warranted.

Keywords: Dodonaea viscosa; antidiarrhea; castor oil; enteropooling; gastrointestinal motility.

PubMed Disclaimer

Conflict of interest statement

Declaration of Conflicting Interests: The author declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

References

    1. Haque MA, Abdullah CS, Romana B, et al. Evaluation of anti-diarrheal and anti-diabetic activities of the stem, barks and leaves of the plant Vernonia cinerea (family: asteraceae). J Appl Pharm Sci. 2013;3:69–72.
    1. United Nations International Children’s Emergency Fund. One is too many: ending child deaths from pneumonia and diarrhoea. https://www.unicef.org/publications/index_93020.html. Published November 2016. Accessed November 14, 2019.
    1. Liu L, Oza S, Hogan D, et al. Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the Sustainable Development Goals. Lancet. 2016;388:3027–3035. - PMC - PubMed
    1. Agegnehu MD, Zeleke LB, Goshu YA, Ortibo YL, Mehretie Adinew Y. Diarrhea prevention practice and associated factors among caregivers of under-five children in Enemay district, Northwest Ethiopia. J Environ Public Health. 2019;2019:5490716. - PMC - PubMed
    1. Bern C, Martines J, de Zoysa I, Glass RI. The magnitude of the global problem of diarrhoeal disease: a ten-year update. Bull World Health Organ. 1992;70:705–714. - PMC - PubMed

MeSH terms