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Observational Study
. 2020 Apr 15;201(8):996-998.
doi: 10.1164/rccm.201909-1845LE.

Females with Cystic Fibrosis Demonstrate a Differential Response Profile to Ivacaftor Compared with Males

Katharine E Secunda  1 , Jennifer S Guimbellot  2 , Borko Jovanovic  1 , Sonya L Heltshe  3 , Scott D Sagel  4 , Steven M Rowe  2 , Manu Jain  1
Affiliations
Observational Study

Females with Cystic Fibrosis Demonstrate a Differential Response Profile to Ivacaftor Compared with Males

Katharine E Secunda et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Differences in clinical response to ivacaftor, by sex. (A) Reduction in annualized pulmonary exacerbation rate after ivacaftor treatment, by sex. Females experienced a greater reduction in annualized pulmonary exacerbation rate than males while receiving ivacaftor. “Pre-Ivacaftor” represents the 2-year period before ivacaftor initiation. “Post-Ivacaftor” represents the 2.25-year period after ivacaftor initiation. (B) Correlation between sweat chloride change and baseline weight after ivacaftor treatment, by sex and age. The strongest correlation between sweat chloride change and baseline weight was seen in males younger than 18 years. PEx = pulmonary exacerbation.
See this image and copyright information in PMC

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