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. 2020 Nov;40(11):2184-2190.
doi: 10.1097/IAE.0000000000002721.

DIABETIC MACULAR ISCHEMIA: Correlation of Retinal Vasculature Changes by Optical Coherence Tomography Angiography and Functional Deficit

Andrew S H Tsai  1   2   3 , Alfred T L Gan  1   2 , Daniel S W Ting  1   2   3 , Chee Wai Wong  1   2   3 , Kelvin Y C Teo  1   2   3 , Anna C S Tan  1   2   3 , Shu Yen Lee  1   2   3 , Tien Yin Wong  1   2   3 , Gavin S W Tan  1   2   3 , Chui Ming Gemmy Cheung  1   2   3
Affiliations

DIABETIC MACULAR ISCHEMIA: Correlation of Retinal Vasculature Changes by Optical Coherence Tomography Angiography and Functional Deficit

Andrew S H Tsai et al. Retina. 2020 Nov.

Abstract

Purpose: To examine the relationship between macular microvasculature parameters and functional changes in persons with diabetic retinopathy (DR).

Methods: Cross-sectional study of 76 eyes with varying levels of DR. Optical coherence tomography angiography (OCTA) quantified superficial and deep perifoveal vessel densities and foveal avascular zone areas. Retinal sensitivity was measured using microperimetry. Optical coherence tomography angiography parameters and retinal sensitivity were correlated.

Results: Deep perifoveal vessel density decreased with increasing severity of DR (adjusted mean 51.93 vs. 49.89 vs. 47.96, P-trend = 0.005). Superficial and deep foveal avascular zone area increased with increasing DR severity (adjusted mean: 235.0 µm vs. 303.4 µm vs. 400.9 µm, P-trend = 0.003 [superficial]; 333.1 µm vs. 513.3 µm vs. 530.2 µm, P-trend = 0.001 [deep]). Retinal sensitivity decreased with increasing DR severity (adjusted mean: 25.12 dB vs. 22.34 dB vs. 20.67 dB, P-trend = 0.003). Retinal sensitivity correlated positively with deep perifoveal vessel density (Pearson's ρ = 0.276, P = 0.020) and inversely with superficial foveal avascular zone area (Pearson's ρ = -0.333, P = 0.010).

Conclusion: Alterations in retinal microvasculature can be observed with OCTA with increasing severity of DR. These changes are correlated with reduced retinal sensitivity. Optical coherence tomography angiography is useful to detect and quantify the microvasculature properties of eyes with diabetic macular ischemia.

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