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. 2019 Dec 12;8(12):675.
doi: 10.3390/foods8120675.

Celiac Antigenicity of Ancient Wheat Species

Maneka Malalgoda  1 , Jae-Bom Ohm  2 , Senay Simsek  1
Affiliations

Celiac Antigenicity of Ancient Wheat Species

Maneka Malalgoda et al. Foods. .

Abstract

Ancient grains have gained renewed interest in the last few years due to their perceived nutritional benefits. The goal of this study was to examine the presence of celiac epitopes in different ancient grains and determine differences in the gliadin protein profile of such grains. To investigate celiac epitopes, an untargeted mass spectrometric method was used, and the gliadin protein profile was studied using reverse phase-HPLC. Our findings show that celiac epitopes can be detected in wheat-related ancient grains, such as einkorn, emmer, and Kamut, indicating that these ancient grains have the potential to elicit the immune response associated with celiac disease. Additionally, the results showed that the gliadin protein composition is significantly different between ancient grain species, which could result in varying functional properties in end-use applications.

Keywords: ancient grains; celiac epitopes; gliadin; proteomics.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Reverse Phase-HPLC profiles of ancient grain species and the corresponding regions for different gliadin protein types.
See this image and copyright information in PMC

References

    1. Shewry P.R., Gebruers K., Andersson A.A.M., Åman P., Piironen V., Lampi A.-M., Boros D., Rakszegi M., Bedő Z., Ward J.L. Relationship between the contents of bioactive components in grain and the release dates of wheat lines in the HEALTHGRAIN diversity screen. J. Agric. Food Chem. 2011;59:928–933. doi: 10.1021/jf103860x. - DOI - PubMed
    1. Shewry P.R., Pellny T.K., Lovegrove A. Is modern wheat bad for health? Nat. Plants. 2016;2:16097. doi: 10.1038/nplants.2016.97. - DOI - PubMed
    1. Shewry P.R., Corol D.I., Jones H.D., Beale M.H., Ward J.L. Defining genetic and chemical diversity in wheat grain by 1H-NMR spectroscopy of polar metabolites. Mol. Nutr. Food Res. 2017;61:1600807. doi: 10.1002/mnfr.201600807. - DOI - PMC - PubMed
    1. Malalgoda M., Simsek S. Celiac disease and cereal proteins. Food Hydrocoll. 2017;68:108–113. doi: 10.1016/j.foodhyd.2016.09.024. - DOI
    1. Zanini B., Villanacci V., De Leo L., Lanzini A. Triticum monococcum in patients with celiac disease: A phase II open study on safety of prolonged daily administration. Eur. J. Nutr. 2015;54:1027–1029. doi: 10.1007/s00394-015-0892-3. - DOI - PubMed

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