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Comment
. 2020 Feb 15;26(4):761-763.
doi: 10.1158/1078-0432.CCR-19-3670. Epub 2019 Dec 16.

A New CDK9 Inhibitor on the Block to Treat Hematologic Malignancies

Clara Alcon  1 , Albert Manzano-Muñoz  1 , Joan Montero  2
Affiliations
Comment

A New CDK9 Inhibitor on the Block to Treat Hematologic Malignancies

Clara Alcon et al. Clin Cancer Res. .

Abstract

CDK9-specific inhibition with AZD4573 impairs cancer-promoting gene expression such as MCL-1 and has been proven effective in hematologic malignancies preclinical models. This new clinical candidate should be further explored in the clinic not only as a monotherapy but also in combination with BH3 mimetics to prevent treatment resistance.See related article by Cidado et al., p. 922.

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