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Comment
. 2020 Feb;10(2):167.
doi: 10.1158/2159-8290.CD-NB2019-139. Epub 2019 Dec 16.

Novel ADC Solidifies Role in Breast Cancer

No authors listed
Comment

Novel ADC Solidifies Role in Breast Cancer

No authors listed. Cancer Discov. 2020 Feb.

Abstract

The antibody-drug conjugate trastuzumab deruxtecan might become a promising new treatment option for patients with metastatic HER2-positive breast cancer whose disease has progressed after multiple therapies. In a phase II trial, the drug was associated with a high objective response rate and long median progression-free survival, although some patients developed serious side effects.

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  • Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer.
    Modi S, Saura C, Yamashita T, Park YH, Kim SB, Tamura K, Andre F, Iwata H, Ito Y, Tsurutani J, Sohn J, Denduluri N, Perrin C, Aogi K, Tokunaga E, Im SA, Lee KS, Hurvitz SA, Cortes J, Lee C, Chen S, Zhang L, Shahidi J, Yver A, Krop I; DESTINY-Breast01 Investigators. Modi S, et al. N Engl J Med. 2020 Feb 13;382(7):610-621. doi: 10.1056/NEJMoa1914510. Epub 2019 Dec 11. N Engl J Med. 2020. PMID: 31825192 Free PMC article. Clinical Trial.

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