Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Dec;576(7787):389-390.
doi: 10.1038/d41586-019-03730-x.

New antibiotics target the outer membrane of bacteria

Comment

New antibiotics target the outer membrane of bacteria

Marcelo C Sousa. Nature. 2019 Dec.
No abstract available

Keywords: Antibiotics; Drug discovery; Microbiology.

PubMed Disclaimer

Comment on

  • Chimeric peptidomimetic antibiotics against Gram-negative bacteria.
    Luther A, Urfer M, Zahn M, Müller M, Wang SY, Mondal M, Vitale A, Hartmann JB, Sharpe T, Monte FL, Kocherla H, Cline E, Pessi G, Rath P, Modaresi SM, Chiquet P, Stiegeler S, Verbree C, Remus T, Schmitt M, Kolopp C, Westwood MA, Desjonquères N, Brabet E, Hell S, LePoupon K, Vermeulen A, Jaisson R, Rithié V, Upert G, Lederer A, Zbinden P, Wach A, Moehle K, Zerbe K, Locher HH, Bernardini F, Dale GE, Eberl L, Wollscheid B, Hiller S, Robinson JA, Obrecht D. Luther A, et al. Nature. 2019 Dec;576(7787):452-458. doi: 10.1038/s41586-019-1665-6. Epub 2019 Oct 23. Nature. 2019. PMID: 31645764
  • A new antibiotic selectively kills Gram-negative pathogens.
    Imai Y, Meyer KJ, Iinishi A, Favre-Godal Q, Green R, Manuse S, Caboni M, Mori M, Niles S, Ghiglieri M, Honrao C, Ma X, Guo JJ, Makriyannis A, Linares-Otoya L, Böhringer N, Wuisan ZG, Kaur H, Wu R, Mateus A, Typas A, Savitski MM, Espinoza JL, O'Rourke A, Nelson KE, Hiller S, Noinaj N, Schäberle TF, D'Onofrio A, Lewis K. Imai Y, et al. Nature. 2019 Dec;576(7787):459-464. doi: 10.1038/s41586-019-1791-1. Epub 2019 Nov 20. Nature. 2019. PMID: 31747680 Free PMC article.

References

    1. World Health Organization. Global Priority List of Antibiotic-Resistant Bacteria to Guide Research, Discovery, and Development of New Antibiotics (WHO, 2017).
    1. Nikaido, H. Microbiol. Mol. Biol. Rev. 67, 593–656 (2003). - PubMed - DOI - PMC
    1. Li, X.-Z. & Nikaido, H. Drugs 64, 159–204 (2004). - PubMed - DOI
    1. Munita, J. M. & Arias, C. A. Microbiol. Spectr. 4, VMBF-0016-2015 (2016). - DOI
    1. Imai, Y. et al. Nature 576, 459–464 (2019). - DOI

LinkOut - more resources