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Review
. 2019 Dec;69(6):546-552.
doi: 10.1007/s13224-019-01236-0. Epub 2019 Jul 13.

Comparative Study of Neoadjuvant Chemotherapy Followed by Definitive Chemoradiotherapy Versus Definitive Chemoradiotherapy Alone in Locally Advanced Carcinoma of Cervix

Aradhna Tripathi  1 , Shyamji Rawat  1
Affiliations
Review

Comparative Study of Neoadjuvant Chemotherapy Followed by Definitive Chemoradiotherapy Versus Definitive Chemoradiotherapy Alone in Locally Advanced Carcinoma of Cervix

Aradhna Tripathi et al. J Obstet Gynaecol India. 2019 Dec.

Abstract

Background: Carcinoma in the cervix is the most common malignancy and the fourth most common cause of death in females worldwide. It is the most common malignancy in India, the increasing incidence of cancer is escalating burden over radiation. This is a prospective randomized study comparing NACT followed by definitive chemoradiation versus chemoradiation.

Materials and methods: This prospective randomized study analyzed 80 cervical cancer patients who were treated at our center during March 2017 and July 2018. Patients were divided into two arms: one received NACT and definitive CT/T and the other received definitive CT/RT. Statistical analysis was done using SPSS V.20 software.

Results: Overall response rate in our study was found to be 96.2%. In the study group, it was 97.5%, whereas in the control group, it was 95%. Majority of patients were in the age group 41-50 years, mainly stage IIb and IIIb. Tumor response in both the arms was similar and statistically significant (Chi2 = 0.348; p > 0.05). The hematologic toxicities ( p > 0.05) were more in the NACT group than in the CCRT group, while gastrointestinal toxicities were slightly higher in the control (statistically insignificant).

Conclusion: NACT with taxane/platin followed by definitive CT/RT is as effective as the standard care in the treatment of locally advanced cervical cancer. It has even shown better results (p value > .005) and is also helpful in reducing systemic micrometastasis and bulk of the disease. It can be used as an alternative to the standard care at the places of long waiting time for the definitive treatment, without compromising the outcome.

Keywords: Cancer cervix; Carboplatin; Indian setup cancer management; Locally advanced cancer cervix; Neo adjuvant chemotherapy; Paclitaxel.

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Conflict of interest statement

Conflict of interestThe authors declare that they have no conflict of interest.

References

    1. Vishwanathan A, Halperin EC, Wazer DE, et al. Principles and practice of radiation oncology. In: Halperin EC, et al., editors. Perez and Brady’s Principles and practice of radiation oncology. 6. Philadelphia: Wolters Kluwer Health; 1934.
    1. Pecorelli S, Zigliani L, Odicino F. Revised FIGO staging for carcinoma of the cervix. Int J Gynecol Obstet. 2009;145:129–135. - PubMed
    1. Human Papillomavirus (HPV) Vaccines: Q & A. Fact sheets: risk factors and possible causes. National Cancer Institute (NCI). 2009. pp. 10–22. Retrieved 2009-11-11.
    1. Bruni L, Barrionuevo-Rosas L, Albero G, et al. ICO Information Centre on HPV and Cancer (HPV Information Centre). Human Papillomavirus and Related Diseases in [Botswana]. Summary Report. 2014.
    1. Narayan S, Sharma N, Kapoor A, et al. Pros and cons of adding of neoadjuvant chemotherapy to standard concurrent chemoradiotherapy in cervical cancer: a regional cancer center experience. J Obstet Gynecol India. 2016;66:385–390. doi: 10.1007/s13224-015-0698-5. - DOI - PMC - PubMed

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