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. 2019 Nov 14;5(11):e02775.
doi: 10.1016/j.heliyon.2019.e02775. eCollection 2019 Nov.

Serum oxidative stress in patients with pulmonary Mycobacterium avium complex disease

Hiroki Wakabayashi  1   2 , Yasuo Matsuzawa  1 , Sho Hayakawa  1 , Tamako Irie  1 , Hagino Rikitake  1 , Ichiro Tatsuno  1
Affiliations

Serum oxidative stress in patients with pulmonary Mycobacterium avium complex disease

Hiroki Wakabayashi et al. Heliyon. .

Abstract

Background: The mechanism of progressive airway destruction in incurable chronic infection of the lung - termed pulmonary Mycobacterium avium complex (pMAC) disease - is currently unknown. The involvement of oxidative stress in a variety of progressive chronic respiratory diseases has been previously reported. It has been hypothesized that oxidative stress may be involved in the progression of airway destruction in pMAC disease.

Patients and methods: The study included 28 untreated patients with pMAC disease. The level of serum oxidative stress was quantitatively evaluated through the diacron reactive oxygen metabolites (d-ROMs) test, which indirectly measures the level of hydroperoxide in the serum. In addition, patients were divided into three groups based on the severity shown in the computed tomographic image.

Results: The level of serum oxidative stress exceeded the normal range (250-300 U.Carr [Carratelli Units]) in all patients with pMAC disease (mean: 495.5 ± 102.6 U.Carr; minimum-maximum: 340-734 U.Carr). The level of serum oxidative stress in patients with severe disease was significantly higher compared with that observed in patients with mild disease (434.6 ± 30.2 vs. 583.4 ± 95.1, respectively, p = 0.009).

Conclusions: In patients with pMAC disease, an elevation was observed in the level of serum oxidative stress. This increase in oxidative stress was more pronounced in patients with severe disease.

Keywords: Biomarkers; Infectious disease; Internal medicine; Medical imaging; Microbiology; Respiratory system.

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Figures

Fig. 1
Fig. 1
These levels exceeded the upper limit of the normal reference value. pMAC: pulmonary Mycobacterium avium complex; U.Carr: Carratelli Units.
Fig. 2
Fig. 2
The level of serum oxidative stress in the severe group was significantly higher than those reported in the mild and moderate groups.
See this image and copyright information in PMC

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References

    1. Namkoong H., Kurashima A., Morimoto K. Epidemiology of pulmonary nontuberculous mycobacterial disease. Japan. Emerg. Infect. Dis. 2016;22(6):1116–1117. - PMC - PubMed
    1. Prevots D.R., Shaw P.A., Strickland D. Nontuberculous mycobacterial lung disease prevalence at four integrated health care delivery systems. Am. J. Respir. Crit. Care Med. 2010;182(7):970–976. - PMC - PubMed
    1. Pasipanodya J.G., Ogbonna D., Deshpande D., Srivastava S., Gumbo T. Meta-analyses and the evidence base for microbial outcomes in the treatment of pulmonary Mycobacterium avium-intracellulare complex disease. J. Antimicrob. Chemother. 2017;72(suppl_2):i3–i19. - PubMed
    1. Karakousis P.C., Moore R.D., Chaisson R.E. Mycobacterium avium complex in patients with HIV infection in the era of highly active antiretroviral therapy. Lancet Infect. Dis. 2004;4(9):557–565. - PubMed
    1. Griffith D.E., Aksamit T., Brown-Elliott B.A. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am. J. Respir. Crit. Care Med. 2007;175(4):367–416. - PubMed

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