Effect of air pollution on hospitalization for acute exacerbation of chronic obstructive pulmonary disease, stroke, and myocardial infarction

Abstract

This study aims to analyze the acute effects of PM_2.5, PM₁₀, SO₂, NO₂, and O₃ on hospitalizations for acute exacerbation of chronic obstructive pulmonary disease (AECOPD), stroke, and myocardial infarction (MI) from 2014 to 2017 in Shenyang, China. Hospitalization records for AECOPD (17,655), stroke (276,736) and MI (26,235) and air pollutions concentration data (PM_2.5, PM₁₀, SO₂, NO₂, and O₃) were collected. A generalized additive model (GAM) was utilized to determine the impact of air pollutants on the relative risk (RR) of hospitalization for AECOPD, stroke, and MI. Stratified analysis for AECOPD was based on gender and age. It was based on gender, age, hypertension, and diabetes for stroke, and for MI it was based on gender, age, and coronary atherosclerosis. The lag effect for AECOPD in terms of gender analysis occurred at lag3-lag5. The hospitalization risk for stroke with hypertension due to SO₂ and NO₂ was greater than that of stroke without hypertension. The risk of hospitalization for stroke with hypertension as a comorbidity due to O₃ was lower than without hypertension. The risk of hospitalization for MI combined with coronary atherosclerosis due to PM_2.5, PM₁₀, or NO₂ was higher than that of hospitalizations for MI without coronary atherosclerosis. Air pollution increased the rate of hospitalization for AECOPD. SO₂ and O₃ appeared protective for stroke patients with coronary atherosclerosis. PM_2.5, PM₁₀, and NO₂ had no influence on total hospitalization for myocardial infarction.

Keywords: Acute exacerbation of chronic obstructive pulmonary disease; Air pollution; Coronary atherosclerosis; Generalized additive model; Hospitalization; Hypertension; Myocardial infarction; Stroke.