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Meta-Analysis
. 2020 Mar-Apr:87:103997.
doi: 10.1016/j.archger.2019.103997. Epub 2019 Dec 10.

Cognitive frailty as a predictor of dementia among older adults: A systematic review and meta-analysis

Lufang Zheng  1 , Guichen Li  1 , Dawei Gao  2 , Shuo Wang  1 , Xiangfei Meng  1 , Cong Wang  1 , Haibo Yuan  3 , Li Chen  4
Affiliations
Meta-Analysis

Cognitive frailty as a predictor of dementia among older adults: A systematic review and meta-analysis

Lufang Zheng et al. Arch Gerontol Geriatr. 2020 Mar-Apr.

Erratum in

Abstract

Objective: The aim of this systematic review and meta-analysis was to synthesize the pooled risk effect and to determine whether cognitive frailty is a predictor of dementia among older adults.

Design: Systematic review and meta-analysis.

Setting and participants: PubMed, EMBASE, Web of Science, and the Cochrane Library were systematically searched until June 5, 2019. Only cohort studies and population-based longitudinal studies published in English were eligible. Study selection, data extraction and quality assessment of including studies were independently completed by two researchers. A fixed-effects model was used to synthesize the risk of baseline cognitive frailty on dementia in the older adults compared with older adults without cognitive frailty.

Measurements: The risk of cognitive frailty on incident dementia.

Results: Of the 1566 identified records, 7 studies met the inclusion criteria and were included in the review. And 4 studies reporting hazard ratio (HR) of incident dementia for cognitive frailty were included in the meta-analysis. Synthesized results showed that baseline cognitive frailty in the elderly was significantly associated with an increased risk of developing dementia as compared with those without cognitive frailty (prefrailty + CI model: pooled HR = 3.99, 95 %CI = 2.94-5.43, p < 0.00001, I2 = 31 %; frailty + CI model: pooled HR = 5.58, 95 %CI = 3.17-9.85, p < 0.00001, I2 = 0 %). Heterogeneity across the studies was low.

Conclusion: Cognitive frailty is a significant predictor of dementia. Cognitive frailty status may be a novel modifiable target in identification of early signs before dementia.

Keywords: Cognitive frailty; Dementia; Older adults.

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Conflict of interest statement

Declaration of Competing Interest We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, there is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in the manuscript entitled.

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