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. 2020 Aug 22;71(5):1324-1326.
doi: 10.1093/cid/ciz1196.

Over-diagnosis of Rotavirus Infection in Infants Due to Detection of Vaccine Virus

David M Whiley  1   2 , Suifang Ye  2   3 , Sarah Tozer  4 , Julia E Clark  5 , Cheryl Bletchly  6 , Stephen B Lambert  4 , Keith Grimwood  7   8 , Graeme R Nimmo  6
Affiliations

Over-diagnosis of Rotavirus Infection in Infants Due to Detection of Vaccine Virus

David M Whiley et al. Clin Infect Dis. .

Abstract

An accurate rotavirus diagnosis is important for clinical management and monitoring active disease and vaccine effectiveness. Between 2016-2018, rotavirus-positive results in our laboratory were from vaccine virus shedding in 71/152 (46.7%) infants with a request for rotavirus testing. Routine infant diagnostic testing should ideally distinguish vaccine from wild-type viruses.

Keywords: diagnosis; rotavirus; shedding; vaccine.

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