Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jan 1:2019:baz135.
doi: 10.1093/database/baz135.

RHPCG: a database of the Regulation of the Hippo Pathway in Cancer Genome

Chengyu Wang  1   2 , Fan Yang  1 , Tingting Chen  1 , Qi Dong  1 , Zhangxiang Zhao  1 , Yaoyao Liu  1 , Bo Chen  1 , Haihai Liang  3 , Huike Yang  2 , Yunyan Gu  1
Affiliations

RHPCG: a database of the Regulation of the Hippo Pathway in Cancer Genome

Chengyu Wang et al. Database (Oxford). .

Abstract

The Hippo signaling pathway is a highly conserved pathway controlling organ size, cell proliferation, apoptosis and other biological functions. Recent studies have shown that Hippo signaling pathway also plays important roles in cancer initiation and progression. However, a database offering multi-omics analyses and visualization of Hippo pathway genes in cancer, as well as comprehensive Hippo regulatory relationships is still lacking. To fill this gap, we constructed the Regulation of the Hippo Pathway in Cancer Genome (RHPCG) database. Currently, RHPCG focuses on analyzing the 21 core Hippo-protein-encoding genes in over 10 000 patients across 33 TCGA (The Cancer Genome Atlas) cancer types at the levels of genomic, epigenomic and transcriptomic landscape. Concurrently, RHPCG provides in its motif section 11 regulatory motif types associated with 21 core Hippo pathway genes containing 180 miRNAs, 6182 lncRNAs, 728 circRNAs and 335 protein coding genes. Thus, RHPCG is a powerful tool that could help researchers understand gene alterations and regulatory mechanisms in the Hippo signaling pathway in cancer.

Keywords: Cancer genome; Hippo signaling pathway; Regulatory motif; The Cancer Genome Atlas.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Statistics of data sources. (A) Statistics of TCGA multi-omic datasets across pan-cancer. (B) Statistics of regulatory patterns derived from databases.
Figure 2
Figure 2
Flow chart of the RHPCG database. (A) Core genes in the Hippo signaling pathway. (B) Dataset statistics in RHPCG. (C) Statistics of regulatory motifs in RHPCG.
Figure 3
Figure 3
Operating instructions of the RHPCG database. (A) Overview of the multi-omics interface of RHPCG. (B) Search by gene section. (C) Search by cancer section. (D) Information box. (E) Multi-omics visualization section. (F) Table of motif results. (G) Network of motifs. (H) Potential targets of the Hippo signaling pathway. (I) Download page of RHPCG.
Figure 4
Figure 4
Type 2 motif (FFLs) subnetworks predicted by RHPCG. (A) Both AMOT and CDX2 are hubs in the type 2 motif (FFLs) subnetworks. (B–D) Box plot of expression of molecules in healthy and patients with HNSC.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Justice R.W., Zilian O., Woods D.F. et al. (1995) The drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev., 9, 534–546. - PubMed
    1. Taha Z., Janse van Rensburg H.J. and Yang X. (2018) The hippo pathway: immunity and cancer. Cancers (Basel)., 10, 4. - PMC - PubMed
    1. Fu V., Plouffe S.W. and Guan K.L. (2017) The hippo pathway in organ development, homeostasis, and regeneration. Curr. Opin. Cell Biol., 49, 99–107. - PMC - PubMed
    1. Zhou Q., Li L., Zhao B. et al. (2015) The hippo pathway in heart development, regeneration, and diseases. Circ. Res., 116, 1431–1447. - PMC - PubMed
    1. Noguchi S., Saito A. and Nagase T. (2018) YAP/TAZ Signaling as a molecular link between fibrosis and cancer. Int. J. Mol. Sci., 19, 11. - PMC - PubMed

Publication types

Substances