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. 2020:2082:211-229.
doi: 10.1007/978-1-0716-0026-9_15.

Quantitative Trait Loci (QTL) Mapping

Kara E Powder  1
Affiliations

Quantitative Trait Loci (QTL) Mapping

Kara E Powder. Methods Mol Biol. 2020.

Abstract

Quantitative trait loci (QTL) are genetic regions that influence phenotypic variation of a complex trait, often through genetic interactions with each other and the environment. These are commonly identified through a statistical genetic analysis known as QTL mapping. Here, I present a step-by-step, practical approach to QTL mapping along with a sample data file. I focus on methods commonly used and discoveries that have been made in fishes, and utilize a multiple QTL mapping (MQM) approach in the free software package R/qtl.

Keywords: Epistasis; Genetic basis; MQM; Quantitative genetics; Quantitative trait locus (QTL).

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