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. 2019 Dec 11:11:10375-10382.
doi: 10.2147/CMAR.S226050. eCollection 2019.

Combined Use of Mean Platelet Volume/Platelet Count Ratio and Platelet Distribution Width to Distinguish Between Patients with Nasopharyngeal Carcinoma, Those with Benign Tumors of the Nasopharynx, and Healthy Subjects

Xuan Zhang  1 , Yuan-Yuan Qin  1 , Min Chen  1 , Yang-Yang Wu  1 , Fa-Quan Lin  1
Affiliations

Combined Use of Mean Platelet Volume/Platelet Count Ratio and Platelet Distribution Width to Distinguish Between Patients with Nasopharyngeal Carcinoma, Those with Benign Tumors of the Nasopharynx, and Healthy Subjects

Xuan Zhang et al. Cancer Manag Res. .

Abstract

Purpose: For the diagnosis of nasopharyngeal carcinoma (NPC), reliable early indicators with sensitivity and specificity should be sought. This study evaluated the effect of the combined use of mean platelet volume/platelet count ratio (MPV/PC ratio) and platelet distribution width (PDW) for differential diagnosis of NPC. In this study, MPV/PC ratio was used for the first time to diagnostically evaluate NPC.

Patients and methods: We retrospectively analyzed various hematological indices of three subject groups (208, 185, and 162 patients with NPC, benign tumors of the nasopharynx, and healthy subjects, respectively) and evaluated the value of combined use of MPV/PC ratio and PDW for differential diagnosis of the three groups using the one-way analysis of variance.

Results: Comparison of laboratory variables between the three groups showed a significant difference in MPV/PC ratio and PDW (P<0.001, all). The MPV/PC ratio in the NPC group was significantly lower than the other two groups (P<0.001); MPV/PC ratio also showed a statistically significant difference in different stages (P=0.034) and serosal invasions (P<0.001) of the NPC group. Receiver operating characteristic curve (ROC) analysis showed that areas under the curve (AUC) of either patients with benign tumors of the nasopharynx (AUCMPV/PCratio+PDW: 0.708) or healthy subjects (AUCMPV/PCratio+PDW: 0.909) were larger than those of MPV/PC ratio (AUCMPV/PCratio: 0.665, 0.869, respectively) and PDW (AUCPDW:0.614, 0.716, respectively) use alone (P<0.05, all).

Conclusion: MPV/PC ratio and PDW may be used as indexes of NPC. MPV/PC ratio combined with PDW could be considered as meaningful laboratory indexes for differential diagnosis of NPC, benign tumors of the nasopharynx, and healthy subjects. This finding could enhance the detection of NPC.

Keywords: mean platelet volume/platelet count ratio; nasopharyngeal carcinoma; platelet distribution width.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
(A) MPV/PC ratio in patients with NPC, those with benign tumors of the nasopharynx, and healthy subjects. (B) PDW in patients with NPC, those with benign tumors of the nasopharynx, and healthy subjects. Abbreviations: MPV/PC ratio, mean platelet volume/platelet count ratio; PDW, platelet distribution width; NPC, nasopharyngeal carcinoma.
Figure 2
Figure 2
(A) MPV/PC ratio between the different stages of the nasopharyngeal carcinoma. (B) MPV/PC ratio between the different serosal invasions of the nasopharyngeal carcinoma. Abbreviation: MPV/PC ratio, mean platelet volume/platelet count ratio.
Figure 3
Figure 3
Receiver operating characteristic curves for MPV/PC ratio and PDW alone or combined to distinguish between the diagnoses of nasopharyngeal carcinoma versus benign tumors of the nasopharynx. Abbreviations: MPV/PC ratio, mean platelet volume/platelet count ratio; PDW, platelet distribution width.
Figure 4
Figure 4
Receiver operating characteristic curves for MPV/PC ratio and PDW alone or combined to distinguish between the diagnoses of nasopharyngeal carcinoma versus healthy subjects. Abbreviations: MPV/PC ratio, mean platelet volume/platelet count ratio; PDW, platelet distribution width.
See this image and copyright information in PMC

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