Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Nov 27:24:96.
doi: 10.4103/jrms.JRMS_197_19. eCollection 2019.

Comparison of oral acetaminophen with oral ibuprofen on closure of symptomatic patent ductus arteriosus in preterm neonates

Mehdi Ghaderian  1 , Behzad Barekatain  2 , Amir Banazade Dardashty  1
Affiliations

Comparison of oral acetaminophen with oral ibuprofen on closure of symptomatic patent ductus arteriosus in preterm neonates

Mehdi Ghaderian et al. J Res Med Sci. .

Abstract

Background: Patent ductus arteriosus (PDA) is a common cause of morbidity in premature neonates. The purpose of this study was to compare the efficacy of oral ibuprofen and oral acetaminophen to closure of symptomatic PDA, in premature neonates with gestational age (GA) ≤32 weeks.

Materials and methods: This study was a randomized clinical trial with forty preterm neonates who were admitted in neonatal intensive care unit with symptomatic PDA and GA ≤32 weeks or birth body weight ≤1500 g. Twenty neonates received oral acetaminophen [Group A] and twenty neonates received oral ibuprofen [Group B] and compared with echocardiography finding each groups for closed PDA before and after treatment regiment.

Results: Our results showed that the primary closure rate of PDA was 70% (95% confidence interval [CI]: 49.9%-90%) and 65% (95% CI: 54.3%-75.7%) in the acetaminophen and ibuprofen groups, respectively, and statistically no significant difference was observed between the two groups (P = 0.74).

Conclusion: These findings suggest that there was no significant difference between the effectiveness of oral acetaminophen and oral ibuprofen on closing of PDA, but less adverse effects and contraindication for acetaminophen make it reasonable choice for the treatment of symptomatic PDA.

Keywords: Acetaminophen; ibuprofen; patent ductus arteriosus.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Algorithm 1
Algorithm 1
The process of treatment in the study groups and switching the patients to different treatment options during the study course
See this image and copyright information in PMC

References

    1. Van Overmeire B, Smets K, Lecoutere D, Van de Broek H, Weyler J, Degroote K, et al. A comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus. N Engl J Med. 2000;343:674–81. - PubMed
    1. Solanky J, Agrawal HK. Effect of oral ibuprofen and oral acetaminophen in the treatment of symptomatic patent ductus arteriosus in premature infants: A hospital based study. Indian J Res. 2017;6:75–7.
    1. Ohlsson A, Walia R, Shah SS. Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants. Cochrane Database Syst Rev. 2013;4:Cd003481. - PubMed
    1. Dani C, Bertini G, Corsini I, Elia S, Vangi V, Pratesi S, et al. The fate of ductus arteriosus in infants at 23-27 weeks of gestation: From spontaneous closure to ibuprofen resistance. Acta Paediatr. 2008;97:1176–80. - PubMed
    1. Katakam LI, Cotten CM, Goldberg RN, Dang CN, Smith PB. Safety and effectiveness of indomethacin versus ibuprofen for treatment of patent ductus arteriosus. Am J Perinatol. 2010;27:425–9. - PMC - PubMed