Comment
doi: 10.1016/j.immuni.2019.11.007.
Back to the Future: Effector Fate during T Cell Exhaustion
Affiliations
- PMID: 31851902
- DOI: 10.1016/j.immuni.2019.11.007
Item in Clipboard
Comment
Back to the Future: Effector Fate during T Cell Exhaustion
Immunity.
.
Free article
Abstract
Exhausted CD8+ T cells adopt a functionally attenuated state but still confer a certain degree of pathogen control. Chen et al. (2019), Hudson et al. (2019), and Zander et al. (2019) assign the lasting maintenance of this restrained pathogen control to an equilibrium of effector-like, transitory, terminal, and memory-like exhausted T cells.
Copyright © 2019 Elsevier Inc. All rights reserved.
Comment on
-
TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision.Immunity. 2019 Nov 19;51(5):840-855.e5. doi: 10.1016/j.immuni.2019.09.013. Epub 2019 Oct 9. Immunity. 2019. PMID: 31606264 Free PMC article.
-
Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection.Immunity. 2019 Dec 17;51(6):1043-1058.e4. doi: 10.1016/j.immuni.2019.11.002. Epub 2019 Dec 3. Immunity. 2019. PMID: 31810882 Free PMC article.
-
CD4+ T Cell Help Is Required for the Formation of a Cytolytic CD8+ T Cell Subset that Protects against Chronic Infection and Cancer.Immunity. 2019 Dec 17;51(6):1028-1042.e4. doi: 10.1016/j.immuni.2019.10.009. Epub 2019 Dec 3. Immunity. 2019. PMID: 31810883 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Research Materials
