Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Dec 17;51(6):980-981.
doi: 10.1016/j.immuni.2019.11.008.

Sweet Temptation: From Sugar Metabolism to Gene Regulation

Giulia Notarangelo  1 , Marcia C Haigis  2
Affiliations
Free article
Comment

Sweet Temptation: From Sugar Metabolism to Gene Regulation

Giulia Notarangelo et al. Immunity. .
Free article

Abstract

In a recent issue of Nature, Zhang et al. (2019) describe an additional histone post-translational modification, named histone lactylation. Following increased lactate production as a consequence of M1 polarization, histone lactylation regulates the induction of an M2-like phenotype in late stages of M1 macrophage activation to promote wound healing.

PubMed Disclaimer

Comment on

  • Metabolic regulation of gene expression by histone lactylation.
    Zhang D, Tang Z, Huang H, Zhou G, Cui C, Weng Y, Liu W, Kim S, Lee S, Perez-Neut M, Ding J, Czyz D, Hu R, Ye Z, He M, Zheng YG, Shuman HA, Dai L, Ren B, Roeder RG, Becker L, Zhao Y. Zhang D, et al. Nature. 2019 Oct;574(7779):575-580. doi: 10.1038/s41586-019-1678-1. Epub 2019 Oct 23. Nature. 2019. PMID: 31645732 Free PMC article.

LinkOut - more resources