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. 2020;79(4-5):301-312.
doi: 10.1159/000503928. Epub 2019 Dec 18.

Exploring the Relationship of Transdiagnostic Mood and Psychosis Symptom Domains with Motor Dysfunction

Jerillyn S Kent  1 , Seth G Disner  2   3 , Abraham C Van Voorhis  4 , Snežana Urošević  2   3 , Michael P Caligiuri  5 , Scott R Sponheim  2   3   6
Affiliations

Exploring the Relationship of Transdiagnostic Mood and Psychosis Symptom Domains with Motor Dysfunction

Jerillyn S Kent et al. Neuropsychobiology. 2020.

Abstract

Background: A number of motor abnormalities have been reported in psychotic disorders, including dyskinesia and psychomotor slowing. There is also evidence for many of the same motor abnormalities in biological first-degree relatives and accruing evidence for motor abnormalities in bipolar disorder. In addition to motor dysfunction, there are also shared symptom domains amongst these populations.

Objectives: We explored the associations of (1) current and lifetime psychosis and mood symptom domains and (2) domains of psychosis proneness with various domains of motor function in a transdiagnostic sample (n = 149).

Method: Individuals with schizophrenia, schizoaffective disorder, or bipolar disorder, biological first-degree relatives of individuals with a psychotic disorder, and controls completed measures of psychomotor speed and movement fluidity, and neural activity related to motor preparation (stimulus-locked lateralized readiness potential, S-LRP) and execution (response-locked LRP) was assessed using EEG. All participants completed the Brief Psychiatric Rating Scale; patients were additionally assessed for lifetime psychosis and mood episode symptoms, and relatives and controls completed the Chapman psychosis proneness scales.

Results: Multiple regression revealed levels of current negative symptoms and mania were significantly positively associated with psychomotor slowing even after accounting for current antipsychotic medication dosage and duration of illness. S-LRP onset latency was significantly positively associated with magical ideation.

Conclusion: Domains of motor function are associated with various mood and psychosis symptom domains in a transdiagnostic sample, which may provide insight into brain abnormalities relevant to the expression of symptoms across disorders.

Keywords: Bipolar disorder; Dyskinesia; Lateralized readiness potential; Psychomotor slowing; Psychosis.

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Conflict of interest statement

Disclosure Statement

The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Associations between BPRS symptom factors and Trails A (* = p<0.05).
Figure 2
Figure 2
Associations between the Chapman scales and S-LRP onset latency (* = p<0.01).
See this image and copyright information in PMC

References

    1. Pappa S, Dazzan P: Spontaneous movement disorders in antipsychotic-naive patients with first-episode psychoses: a systematic review. Psychological medicine 2009;39:1065–1076. - PubMed
    1. Koning JP, Tenback DE, van Os J, Aleman A, Kahn RS, van Harten PN: Dyskinesia and parkinsonism in antipsychotic-naive patients with schizophrenia, first-degree relatives and healthy controls: a meta-analysis. Schizophrenia bulletin 2010;36:723–731. - PMC - PubMed
    1. Bombin I, Arango C, Buchanan RW: Significance and meaning of neurological signs in schizophrenia: two decades later. Schizophrenia bulletin 2005;31:962–977. - PubMed
    1. Morrens M, Hulstijn W, Sabbe B: Psychomotor slowing in schizophrenia. Schizophrenia bulletin 2007;33:1038–1053. - PMC - PubMed
    1. Walther S, Strik W: Catatonia. CNS spectrums 2016;21:341–348. - PubMed