Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Feb;301(2):591-602.
doi: 10.1007/s00404-019-05412-5. Epub 2019 Dec 18.

Reasons for low cervical cancer survival in new accession European Union countries: a EUROCARE-5 study

Magdalena Bielska-Lasota  1 , Silvia Rossi  2 , Michalina Krzyżak  3 , Annemie Haelens  4 , Augius Domenic  5 , Roberta De Angelis  2 , Adam Maciejczyk  6 , Miguel Rodríguez-Barranco  7   8 , Vesna Zadnik  9 , Pamela Minicozzi  10   11 ; EUROCARE-5 Working Group
Collaborators, Affiliations
Free article

Reasons for low cervical cancer survival in new accession European Union countries: a EUROCARE-5 study

Magdalena Bielska-Lasota et al. Arch Gynecol Obstet. 2020 Feb.
Free article

Abstract

Purpose: With better access to early diagnosis and appropriate treatment, cervical cancer (CC) burden decreased in several European countries. In Eastern European (EE) countries, which accessed European Union in 2004, CC survival was worse than in the rest of Europe. The present study investigates CC survival differences across five European regions, considering stage at diagnosis (local, regional and metastatic), morphology (mainly squamous versus glandular tumours) and patients' age.

Methods: We analysed 101,714 CC women diagnosed in 2000-2007 and followed-up to December 2008. Age-standardised 5-year relative survival (RS) and the excess risks of cancer death in the 5 years after diagnosis were computed.

Results: EE women were older and less commonly diagnosed with glandular tumours. Proportions of local stage cancers were similar across Europe, while morphology- and stage-specific RS (especially for non-metastatic disease) were lower in Eastern Europe. Adjusting for age and morphology, excess risk of local stage CC death for EE patients remained higher than that for other European women.

Conclusion: Stage, age and morphology alone do not explain worse survival in Eastern Europe: less effective care may play a role, probably partly due to fewer or inadequate resources being allocated to health care in this area, compared to the rest of Europe.

Keywords: Cervical cancer; Europe; Morphology; Population-based study; Stage at diagnosis; Survival.

PubMed Disclaimer

References

    1. von Karsa L, Anttila A, Ronco G, Ponti A, Malila N, Arbyn M et al (2008) Cancer screening in the European Union. Report on the implementation of the Council Recommendation on cancer screening, 1st edn. European Communities, Brussels
    1. IARC (2018) The Global Cancer Observatory. https://gco.iarc.fr . Accessed 14 Nov 2019
    1. National Cancer Institute (1999) NCI Issues Clinical Announcement on Cervical Cancer: Chemotherapy Plus Radiation Improves Survival. https://www3.scienceblog.com/community/older/archives/B/nih478.html . Accessed 14 Nov 2019
    1. Sant M, Chirlaque Lopez MD, Agresti R, Sánchez Pérez MJ, Holleczek B, Bielska-Lasota M et al (2015) Survival of women with cancers of breast and genital organs in Europe 1999–2007: results of the EUROCARE-5 study. Eur J Cancer 51:2191–2205 - DOI
    1. Romaniuk P, Szromek AR (2016) The evolution of the health system outcomes in Central and Eastern Europe and their association with social, economic and political factors: an analysis of 25 years of transition. BMC Health Serv Res 16:95 - DOI

Publication types