Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2020 Jan;30(1):97-101.
doi: 10.1111/vec.12910. Epub 2019 Dec 19.

Prevalence and impact of cholecystitis on outcome in dogs with gallbladder mucocele

Erin Rogers  1 , Jared A Jaffey  1 , Amber Graham  1 , Eric T Hostnik  2 , Casandra Jacobs  3 , William Fox-Alvarez  4 , Eric Van Eerde  5 , John Arango  6 , Fred Williams 3rd  7 , Amy E DeClue  1
Affiliations
Multicenter Study

Prevalence and impact of cholecystitis on outcome in dogs with gallbladder mucocele

Erin Rogers et al. J Vet Emerg Crit Care (San Antonio). 2020 Jan.

Abstract

Background: Gallbladder mucocele is a potentially life-threatening extrahepatic biliary disease in dogs. The primary aims of this study were to evaluate the prevalence of cholecystitis in dogs with gross and histopathologically confirmed gallbladder mucocele and to investigate if there is an association between cholecystitis, including its subtypes (eg, acute, acute on chronic, with necrosis, chronic), and survival. Our secondary objective was to evaluate if there is an association between cholecystitis and intraoperative bacteriological culture positivity.

Key findings: Two hundred nineteen dogs with gallbladder mucocele were included in this multi-institutional retrospective study, of which 63 (28.8%) dogs had histopathological evidence of cholecystitis. The most common forms of cholecystitis were acute on chronic (n = 22/63, 34.9%) and with necrosis (n = 20, 31.7%). Thirty-one (14.1%) dogs had growth of at least 1 bacterial isolate; however, 88.7% had antimicrobials administered within the 48 hours before surgery or intraoperatively. There was not an association between cholecystitis or its subtypes and survival. Furthermore, there was not an association between cholecystitis and intraoperative bacteriological culture positivity. A total of 38 (17.4%) dogs either died or were euthanized during hospitalization.

Significance: Cholecystitis is a common comorbidity in dogs with gallbladder mucocele but was not associated with decreased survival.

Keywords: Tokyo guidelines; cholecystectomy; cholecystitis with necrosis.

PubMed Disclaimer

References

REFERENCES

    1. Besso JG, Wrigley RH, Gliatto JH, Webster CRL. Ultrasonographic appearance and clinical findings in 14 dogs with gallbladder mucocele. Vet Radiol Ultrasound. 2000;41:261-271.
    1. Bargellini P, Orlandi R, Paloni C, et al. Evaluation of contrast-enhanced ultrasonography as a method for detecting gallbladder necrosis or rupture in dogs. Vet Radiol Ultrasound. 2006;57:611-620.
    1. Kimura Y, Takada T, Kawarada Y, et al. Definitions, pathophysiology, and epidemiology of acute cholangitis and cholecystitis: Tokyo guidelines. J Hepatobiliary Pancreat Surg. 2007;14:15-26.
    1. Hirota M, Takada T, Kawarada Y, et al. Diagnostic criteria and severity assessment of acute cholecystitis: Tokyo guidelines. J Hepatobiliary Pancreat Sci. 2007;14:78-82.
    1. Tamborini A, Jahns H, McAllister H, et al. Bacterial cholangitis, cholecystitis, or both in dogs. J Vet Intern Med. 2016;30:1046-1055.

Publication types

LinkOut - more resources