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. 2020 Dec;23(6):438-444.
doi: 10.1089/pop.2019.0089. Epub 2019 Dec 17.

The Patient-Centered Outcomes Research Network Antibiotics and Childhood Growth Study: Implementing Patient Data Linkage

Melanie Canterberry  1 , Alan F Kaul  2 , Satyender Goel  3 , Pi-I Debby Lin  4 , Jason P Block  4 , Vinit P Nair  5 , Qianli Ma  5 , Thomas W Carton  1
Affiliations

The Patient-Centered Outcomes Research Network Antibiotics and Childhood Growth Study: Implementing Patient Data Linkage

Melanie Canterberry et al. Popul Health Manag. 2020 Dec.

Abstract

PCORnet, the Patient-Centered Outcomes Research Network, is comprised of health systems and health plans that transform electronic health records (EHRs) and claims data to a common data model (CDM) to facilitate real-world clinical research. Because patients receive health care in multiple care delivery settings, linking health records across systems and health plan claims would provide a more comprehensive and accurate picture of health care for patients. The current study expanded on a PCORnet Antibiotics and Childhood Growth (ABX) study to (1) identify and implement a privacy-preserving patient linkage solution among a clinical data research network and a health plan network within the ABX Study, and (2) assess overlap in prescribed and dispensed antibiotics and additional data gained from claims among the linked patients. This manuscript describes the linkage process and resulting overlap analysis. The authors identified 549 patients from the EHR record study cohort who had claims records with the health plan. Sixty percent (n = 329) of patients had consistent antibiotic exposure data across the 2 sources, indicating antibiotic exposure (44.3%) or nonexposure (15.7%). Among total antibiotic prescribing records, 43.1% had a matched claims record for dispensing within 60 days. Among antibiotic dispense records 26.5% were not associated with a prescribing record in the linked health systems. These findings showcase the feasibility of linking health plan claims data to PCORnet CDM in a privacy-preserving manner while also demonstrating continued gaps in data that may occur. The study highlights the importance of combining multiple health data sources for comprehensive clinical research.

Keywords: childhood antibiotics; electronic health records; patient data linkage.

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Conflict of interest statement

Author Disclosure Statement

The authors declare that there are no conflicts of interest.

Figures

FIG. 1.
FIG. 1.
Anonymous record linkage and data curation process flow for building linked ABX cohort used in the study. ABX, Antibiotics and Childhood Growth; HDL, Health Data Link, Inc.; REACHnet, Research Action for Health Network.
FIG. 2.
FIG. 2.
Number of matched antibiotic prescribing (REACHnet) and dispensing (HUMnet) episodes (0 < 2 years). REACHnet, Research Action for Health Network.
See this image and copyright information in PMC

References

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