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Book

Cephalosporins

Toai Bui  1 , Preeti Patel, Charles V. Preuss  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
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Book

Cephalosporins

Toai Bui et al.
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Excerpt

Cephalosporins are β-lactam antimicrobials used to manage various infections caused by both gram-positive and gram-negative bacteria. The 5 generations of cephalosporins demonstrate efficacy in treating skin and soft tissue infections, pneumonia, meningitis, and other infections. Cefiderocol is a novel siderophore cephalosporin that exhibits remarkable antibacterial activity. This drug has been approved by the US Food and Drug Administration (FDA) to treat complicated urinary tract infections and ventilator-associated pneumonia caused by highly resistant gram-negative bacteria, including Klebsiella pneumonia, Proteus mirabilis, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii.

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Conflict of interest statement

Disclosure: Toai Bui declares no relevant financial relationships with ineligible companies.

Disclosure: Preeti Patel declares no relevant financial relationships with ineligible companies.

Disclosure: Charles Preuss declares no relevant financial relationships with ineligible companies.

References

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    1. Griffith RS. The pharmacology of cephalexin. Postgrad Med J. 1983;59 Suppl 5:16-27. - PubMed
    1. Bergeron MG, Brusch JL, Barza M, Weinstein L. Bactericidal activity and pharmacology of cefazolin. Antimicrob Agents Chemother. 1973 Oct;4(4):396-401. - PMC - PubMed
    1. Tartaglione TA, Polk RE. Review of the new second-generation cephalosporins: cefonicid, ceforanide, and cefuroxime. Drug Intell Clin Pharm. 1985 Mar;19(3):188-98. - PubMed
    1. Klein NC, Cunha BA. Third-generation cephalosporins. Med Clin North Am. 1995 Jul;79(4):705-19. - PubMed

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