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Multicenter Study
. 2020 Jan;49(1):34-38.
doi: 10.1097/MPA.0000000000001460.

Safety of Endoscopic Ultrasound-Guided Fine-Needle Aspiration for Pancreatic Solid Pseudopapillary Neoplasm Before Surgical Resection: A European Multicenter Registry-Based Study on 149 Patients

David Karsenti  1 , Fabrice Caillol  2 , Ulriikka Chaput  3 , Bastien Perrot  4 , Stéphane Koch  5 , Lucine Vuitton  5 , Jérémie Jacques  6 , Jean-Christophe Valats  7 , Laurent Poincloux  8 , Clément Subtil  9 , Edouard Chabrun  9 , Nicolas Williet  10 , Geoffroy Vanbiervliet  11 , Hichem Belkhodja  12 , Antoine Charachon  13 , Marc Wangermez  14 , Emmanuel Coron  15 , Franck Cholet  16 , Jocelyn Privat  17 , Yann Le Baleur  18 , Philippe Bichard  19 , Philippe Ah Soune  20 , Stéphane Lecleire  21 , Maxime Palazzo  22 ; from the GRAPHE
Affiliations
Multicenter Study

Safety of Endoscopic Ultrasound-Guided Fine-Needle Aspiration for Pancreatic Solid Pseudopapillary Neoplasm Before Surgical Resection: A European Multicenter Registry-Based Study on 149 Patients

David Karsenti et al. Pancreas. 2020 Jan.

Abstract

Objectives: The results of only a few endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) for pancreatic solid pseudopapillary neoplasm (SPN) have been published, and the safety of the procedure has never been investigated. Our study compared the recurrence rate in patients with and without preoperative EUS-FNA.

Methods: This European multicenter registry-based study was conducted in 22 digestive units, and retrospectively included all patients who underwent complete resection of a pancreatic SPN from 2000 to 2018. Patients with and without initial EUS-FNA were compared, and postsurgery recurrence and the associated risk factors were evaluated.

Results: A complete resection of a pancreatic SPN was performed in 149 patients (133 women, 89%), with a mean age of 34 (standard deviation, 14) years. There were no significant differences between the with (78 patients) and without (71 patients) EUS-FNA groups, except for age and tumor size and location.Preoperative EUS-FNA allowed pancreatic SPN diagnosis in 63/78 cases (81%). After a mean follow-up of 43 (standard deviation, 36) months, recurrence was noted in 4 patients (2.7%). Preoperative EUS-FNA was not correlated with recurrence, but an older age (P = 0.005) was significant.

Conclusions: Preoperative EUS-FNA does not affect pancreatic SPN recurrence. In this series, old age was significantly correlated with recurrence.

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