Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Dec 19;134(25):2227-2229.
doi: 10.1182/blood.2019003651.

Translating exercise benefits in sickle cell disease

Dan M Cooper  1 , Robert I Liem  2
Affiliations
Comment

Translating exercise benefits in sickle cell disease

Dan M Cooper et al. Blood. .

Abstract

The pathophysiologic basis for reduced fitness in sickle cell disease (SCD) is multifactorial and characterized by impaired oxygen-carrying capacity, derangements in the cardiopulmonary response to exercise, and abnormal metabolic responses in working muscles. In this issue of Blood, Merlet et al demonstrated in a provocative and elegant study that exercise training led to muscle capillary growth in people with SCD.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Figures

None
Leveraging innovative data science approaches to exercise laboratory testing and field assessments is a translational imperative in SCD that may lead to the development of novel biomarkers for new therapies and evidence-based exercise prescription. ECG, electrocardiogram.
See this image and copyright information in PMC

Comment on

References

    1. Merlet AN, Messonnier LA, Coudy-Gandilhon C, et al. . Beneficial effects of endurance exercise training on skeletal muscle microvasculature in sickle cell disease patients. Blood. 2019;2233-2241. - PubMed
    1. Sarray S, Saleh LR, Lisa Saldanha F, Al-Habboubi HH, Mahdi N, Almawi WY. Serum IL-6, IL-10, and TNFα levels in pediatric sickle cell disease patients during vasoocclusive crisis and steady state condition. Cytokine. 2015;72(1):43-47. - PubMed
    1. Fadini GP, Spinetti G, Santopaolo M, Madeddu P. Impaired regeneration contributes to poor outcomes in diabetic peripheral artery disease [published online ahead of print 12 September 2019]. Arterioscler Thromb Vasc Biol. 2019;A119312863. - PubMed
    1. Buchowski MS, Townsend KM, Williams R, Chen KY. Patterns and energy expenditure of free-living physical activity in adolescents with sickle cell anemia. J Pediatr. 2002;140(1):86-92. - PubMed
    1. Lammers G, van Duijnhoven NTL, Hoenderop JG, et al. . The identification of genetic pathways involved in vascular adaptations after physical deconditioning versus exercise training in humans. Exp Physiol. 2013;98(3):710-721. - PubMed