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Review
. 2020 Apr;33(2):239-249.
doi: 10.1007/s40620-019-00685-0. Epub 2019 Dec 19.

Vitamin K effects in human health: new insights beyond bone and cardiovascular health

Maria Fusaro  1   2 , Maurizio Gallieni  3 , Camillo Porta  4   5 , Thomas L Nickolas  6 , Pascale Khairallah  6
Affiliations
Free article
Review

Vitamin K effects in human health: new insights beyond bone and cardiovascular health

Maria Fusaro et al. J Nephrol. 2020 Apr.
Free article

Erratum in

Abstract

Vitamin K is a cofactor for the function of the enzyme γ-glutamyl carboxylase, necessary for the activation of multiple vitamin K dependent-proteins. Vitamin K dependent-proteins (VKDPs) have important roles in bone health, vascular health, metabolism, reproduction as well as in cancer progression. Vitamin K deficiency is common in different conditions, including kidney disease, and it may influence the activity of VKDPs. This review discusses vitamin K status in human health and the physiologic and pathologic roles of VKDPs, beyond the established effects in skeletal and cardiovascular health.

Keywords: Bone disease; Cancer; Chronic kidney disease; Vascular calcifications; Vitamin K.

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