Addiction Research Consortium: Losing and regaining control over drug intake (ReCoDe)-From trajectories to mechanisms and interventions

Andreas Heinz¹, Falk Kiefer², Michael N Smolka³, Tanja Endrass⁴, Christian Beste⁵, Anne Beck¹, Shuyan Liu¹, Alexander Genauck¹, Lydia Romund¹, Tobias Banaschewski⁶, Felix Bermpohl¹, Lorenz Deserno^{3

7}, Raymond J Dolan⁷, Daniel Durstewitz⁸, Ulrich Ebner-Priemer⁹, Herta Flor^{10

11}, Anita C Hansson¹², Christine Heim^{13

14}, Derik Hermann^{2

15}, Stefan Kiebel^{3

16}, Peter Kirsch¹⁷, Clemens Kirschbaum¹⁸, Georgia Koppe⁸, Michael Marxen³, Andreas Meyer-Lindenberg¹⁹, Wolfgang E Nagel²⁰, Hamid R Noori^{12

21}, Maximilian Pilhatsch²², Josef Priller^{23

24}, Marcella Rietschel²⁵, Nina Romanczuk-Seiferth¹, Florian Schlagenhauf¹, Wolfgang H Sommer^{2

12}, Jan Stallkamp²⁶, Andreas Ströhle¹, Ann-Kathrin Stock⁵, Georg Winterer²⁷, Christine Winter¹, Henrik Walter¹, Stephanie Witt²⁵, Sabine Vollstädt-Klein², Michael A Rapp²⁸, Heike Tost¹⁹, Rainer Spanagel¹²

Affiliations

¹ Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin (Campus Charité Mitte), Berlin, Germany.
² Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
³ Department of Psychiatry and Neuroimaging Centre, Technische Universität Dresden, Dresden, Germany.
⁴ Institute for Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
⁵ Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Technische Universität Dresden, Dresden, Germany.
⁶ Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
⁷ Max Planck Centre for Computational Psychiatry and Ageing Research & Wellcome Centre for Human Neuroimaging, University College London, London, UK.
⁸ Department of Theoretical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
⁹ Department of Sports and Sports Science, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
¹⁰ Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
¹¹ Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
¹² Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
¹³ Institute of Medical Psychology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
¹⁴ Department of Biobehavioral Health, Pennsylvania State University, University Park, Pennsylvania.
¹⁵ Feuerlein Center on Translational Addiction Medicine (FCTS), University of Heidelberg, Heidelberg, Germany.
¹⁶ Department of Psychology and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
¹⁷ Department of Clinical Psychology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
¹⁸ Department of Psychology, Biological Psychology, Technische Universität Dresden, Dresden, Germany.
¹⁹ Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
²⁰ Center for Information Services and High Performance Computing, Technische Universität Dresden, Dresden, Germany.
²¹ Max Planck Institute for Biological Cybernetics, Tübingen, Germany.
²² Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
²³ Department of Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité-Universitätsmedizin Berlin, Berlin, Germany.
²⁴ UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
²⁵ Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
²⁶ Project Group for Automation in Medicine and Biotechnology, Fraunhofer IPA, Mannheim, Germany.
²⁷ Experimental and Clinical Research Center (ECRC), Department of Anesthesiology and Intensive Care Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.
²⁸ Social and Preventive Medicine, Universität Potsdam, Potsdam, Germany.

PMID: 31859437
DOI: 10.1111/adb.12866

Review

Addiction Research Consortium: Losing and regaining control over drug intake (ReCoDe)-From trajectories to mechanisms and interventions

Andreas Heinz et al. Addict Biol. 2020 Mar.

. 2020 Mar;25(2):e12866.

doi: 10.1111/adb.12866. Epub 2019 Dec 20.

Authors

Affiliations

¹ Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin (Campus Charité Mitte), Berlin, Germany.
² Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
³ Department of Psychiatry and Neuroimaging Centre, Technische Universität Dresden, Dresden, Germany.
⁴ Institute for Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
⁵ Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Technische Universität Dresden, Dresden, Germany.
⁶ Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
⁷ Max Planck Centre for Computational Psychiatry and Ageing Research & Wellcome Centre for Human Neuroimaging, University College London, London, UK.
⁸ Department of Theoretical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
⁹ Department of Sports and Sports Science, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
¹⁰ Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
¹¹ Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
¹² Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
¹³ Institute of Medical Psychology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
¹⁴ Department of Biobehavioral Health, Pennsylvania State University, University Park, Pennsylvania.
¹⁵ Feuerlein Center on Translational Addiction Medicine (FCTS), University of Heidelberg, Heidelberg, Germany.
¹⁶ Department of Psychology and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
¹⁷ Department of Clinical Psychology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
¹⁸ Department of Psychology, Biological Psychology, Technische Universität Dresden, Dresden, Germany.
¹⁹ Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
²⁰ Center for Information Services and High Performance Computing, Technische Universität Dresden, Dresden, Germany.
²¹ Max Planck Institute for Biological Cybernetics, Tübingen, Germany.
²² Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
²³ Department of Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité-Universitätsmedizin Berlin, Berlin, Germany.
²⁴ UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
²⁵ Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
²⁶ Project Group for Automation in Medicine and Biotechnology, Fraunhofer IPA, Mannheim, Germany.
²⁷ Experimental and Clinical Research Center (ECRC), Department of Anesthesiology and Intensive Care Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.
²⁸ Social and Preventive Medicine, Universität Potsdam, Potsdam, Germany.

PMID: 31859437
DOI: 10.1111/adb.12866

Abstract

One of the major risk factors for global death and disability is alcohol, tobacco, and illicit drug use. While there is increasing knowledge with respect to individual factors promoting the initiation and maintenance of substance use disorders (SUDs), disease trajectories involved in losing and regaining control over drug intake (ReCoDe) are still not well described. Our newly formed German Collaborative Research Centre (CRC) on ReCoDe has an interdisciplinary approach funded by the German Research Foundation (DFG) with a 12-year perspective. The main goals of our research consortium are (i) to identify triggers and modifying factors that longitudinally modulate the trajectories of losing and regaining control over drug consumption in real life, (ii) to study underlying behavioral, cognitive, and neurobiological mechanisms, and (iii) to implicate mechanism-based interventions. These goals will be achieved by: (i) using mobile health (m-health) tools to longitudinally monitor the effects of triggers (drug cues, stressors, and priming doses) and modify factors (eg, age, gender, physical activity, and cognitive control) on drug consumption patterns in real-life conditions and in animal models of addiction; (ii) the identification and computational modeling of key mechanisms mediating the effects of such triggers and modifying factors on goal-directed, habitual, and compulsive aspects of behavior from human studies and animal models; and (iii) developing and testing interventions that specifically target the underlying mechanisms for regaining control over drug intake.

Keywords: addiction; alternative rewards; animal and computational models; cognitive-behavioral control; craving and relapse; habit formation.

PubMed Disclaimer

References

REFERENCES

1. Helzer JE, Robins LN, Taylor JR, et al. The extent of long-term moderate drinking among alcoholics discharged from medical and psychiatric treatment facilities. N Engl J Med. 1985;312(26):1678-1682.
1. Imber S, Schultz E, Funderburk F, Allen R, Flamer R. The fate of the untreated alcoholic. Toward a natural history of the disorder. J Nerv Ment Dis. 1976;162(4):238-247.
1. Sobell LC, Ellingstad TP, Sobell MB. Natural recovery from alcohol and drug problems: methodological review of the research with suggestions for future directions. Addiction. 2000;95(5):749-764.
1. Swift W, Coffey C, Degenhardt L, Carlin JB, Romaniuk H, Patton GC. Cannabis and progression to other substance use in young adults: findings from a 13-year prospective population-based study. J Epidemiol Community Health. 2012;66(7):e26.
1. Mann K, Schafer DR, Langle G, Ackermann K, Croissant B. The long-term course of alcoholism, 5, 10 and 16 years after treatment. Addiction. 2005;100(6):797-805.

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
- Ovid Technologies, Inc.
- Wiley
Medical

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Addiction Research Consortium: Losing and regaining control over drug intake (ReCoDe)-From trajectories to mechanisms and interventions

Affiliations

Addiction Research Consortium: Losing and regaining control over drug intake (ReCoDe)-From trajectories to mechanisms and interventions

Authors

Affiliations

Abstract

References

REFERENCES

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical