doi: 10.1016/0304-3940(88)90693-3.
Epidermal growth factor receptor immunoreactivity in rat brain astrocytes. Response to injury
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- PMID: 3185965
- DOI: 10.1016/0304-3940(88)90693-3
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Epidermal growth factor receptor immunoreactivity in rat brain astrocytes. Response to injury
Neurosci Lett.
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Abstract
Brain astroglia in normal adult rats stained weakly or not at all with an antibody to epidermal growth factor receptor (EGFR). A dramatic change took place after injury. The astrocytes adjacent to an entorhinal ablation and in deafferented areas of the hippocampus showed prominent EGFR immunoreactivity. Cells that were EFGR-immunoreactive also stained intensely with an antibody to glial fibrillary acidic protein (GFAP). The localization and the time course of appearance of EGFR/GFAP immunoreactivity suggests that EGFR may be involved in the conversion of a normal into a reactive astrocyte.
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