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Review
. 2020 Mar 1;93(1107):20190469.
doi: 10.1259/bjr.20190469. Epub 2020 Jan 3.

Is there a role for arcing techniques in proton therapy?

Alejandro Carabe-Fernandez  1 , Alejandro Bertolet-Reina  1 , Ilias Karagounis  1 , Kiet Huynh  1 , Roger G Dale  2
Affiliations
Review

Is there a role for arcing techniques in proton therapy?

Alejandro Carabe-Fernandez et al. Br J Radiol. .

Abstract

Proton arc therapy (PAT) has been proposed as a possible evolution for proton therapy. This commentary uses dosimetric and cancer risk evaluations from earlier studies to compare PAT with intensity modulated proton therapy. It is concluded that, although PAT may not produce better physical dose distributions than intensity modulated proton therapy, the radiobiological considerations associated with particular PAT techniques could offer the possibility of an increased therapeutic index.

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Figures

Figure 1.
Figure 1.
Left, Clonogenic assay showing a larger radiobiological effectiveness of PAT vs IMPT for H1299 cells. Right, relative dose of IMPT required to induce the same biological effect as PAT obtained from the clonogenic plots. Dashed lines represent the calculated 95% CI for this quantity. CI, confidence interval; IMPT, intensity modulated proton therapy; PAT, proton arc therapy.
See this image and copyright information in PMC

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