Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2019 Dec;98(51):e18518.
doi: 10.1097/MD.0000000000018518.

The association between rs12807809 polymorphism in neurogranin gene and risk of schizophrenia: A meta-analysis

Lu Jin  1 , Zhiguo An  1 , Bin Xu  1 , Daibin Mu  1 , Songnian Fu  1 , Hongxing Hu  1 , Yongyong Shi  2 , Xiao Luo  1 , Qizhong Yi  1
Affiliations
Meta-Analysis

The association between rs12807809 polymorphism in neurogranin gene and risk of schizophrenia: A meta-analysis

Lu Jin et al. Medicine (Baltimore). 2019 Dec.

Abstract

Background: The correlation between single nucleotide polymorphism (SNP) rs12807809 in Neurogranin (NRGN) gene and Schizophrenia (SCZ) was investigated by several studies, whereas the results were conflicting. Thus, we performed the present meta-analysis to combine and analyze the available studies in order to provide a more accurate result on the association of rs12807809 polymorphism in NRGN gene and SCZ vulnerability.

Methods: A comprehensive retrieval in PubMed, EMBASE, Web of Science, Cochrane Library and Wanfang was performed for relevant studies on the relationship of rs12807809 polymorphism and SCZ. Summary odds ratios (OR) with 95% confidence interval (95% CI) were calculated in allelic, homozygous, heterozygous, dominant and recessive model to appraise the association.

Results: The meta-analysis included 8 studies containing 12552 SCZ cases and 34783 controls. The results showed a statistically significant correlation between SCZ and rs12807809 polymorphism in overall population in allelic model (OR = 1.10, 95%CI 1.04-1.17). However, subgroup analysis indicated the association only existed in Caucasians but not Asian.

Conclusion: The results of present meta-analysis suggested significant association between SNP rs12807809 in NRGN gene and SCZ susceptibility in Caucasians but not Asians.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest.

Figures

Figure 1
Figure 1
Flow diagram of literature retrieval and selection.
Figure 2
Figure 2
Calculated OR and 95% CI for the association rs12807809 polymorphism and Schizophrenia risk in the allelic model for overall populations. Forest plot of association between rs12807809 and risk of Schizophrenia for allelic model (T vs C).
Figure 3
Figure 3
Forest plot of rs12807809 polymorphism and risk of Schizophrenia using a random-effect model: subgroup-analysis by ethnicity.
Figure 4
Figure 4
Association between rs12807809 polymorphism and risk of Schizophrenia under allelic model with Sudesh et al's study excluded.
Figure 5
Figure 5
Association between rs12807809 polymorphism and risk of Schizophrenia under recessive model with Sudesh et al's study excluded.
Figure 6
Figure 6
Funnel plot of rs12807809 polymorphism and risk of Schizophrenia.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Rethelyi JM, Benkovits J, Bitter I. Genes and environments in schizophrenia: The different pieces of a manifold puzzle. Neurosci Biobehav Rev 2013;37:2424–37. - PubMed
    1. Gejman PV, Sanders AR, Kendler KS. Genetics of schizophrenia: new findings and challenges. Annu Rev Genomics Hum Genet 2011;12:121–44. - PubMed
    1. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature 2014;511:421–7. - PMC - PubMed
    1. Zhou Y, Dong F, Lanz TA, et al. Interactome analysis reveals ZNF804A, a schizophrenia risk gene, as a novel component of protein translational machinery critical for embryonic neurodevelopment. Mol Psychiatry 2018;23:952–62. - PMC - PubMed
    1. Girard SL, Dion PA, Rouleau GA. Schizophrenia genetics: putting all the pieces together. Curr Neurol Neurosci Rep 2012;12:261–6. - PubMed