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Review
. 2019 Dec 19;10(1):4.
doi: 10.3390/diagnostics10010004.

Animal Models of Post-Traumatic Epilepsy

Kristin A Keith  1   2 , Jason H Huang  1   2
Affiliations
Review

Animal Models of Post-Traumatic Epilepsy

Kristin A Keith et al. Diagnostics (Basel). .

Abstract

Traumatic brain injury is the leading cause of morbidity and mortality worldwide, with the incidence of post-traumatic epilepsy increasing with the severity of the head injury. Post-traumatic epilepsy (PTE) is defined as a recurrent seizure disorder secondary to trauma to the brain and has been described as one of the most devastating complications associated with TBI (Traumatic Brain Injury). The goal of this review is to characterize current animal models of PTE and provide succinct protocols for the development of each of the currently available animal models. The development of translational and effective animal models for post-traumatic epilepsy is critical in both elucidating the underlying pathophysiology associated with PTE and providing efficacious clinical breakthroughs in the management of PTE.

Keywords: acceleration impact model; animal models; controlled cortical impact model; fluid percussion injury; pediatric traumatic brain injury; penetrating brain injury; post-traumatic epilepsy; traumatic brain injury; weight drop model.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Dewan M.C., Rattani A., Gupta S., Baticulon R.E., Hung Y.-C., Punchak M., Agrawal A., Adeleye A.O., Shrime M.G., Rubiano A.M., et al. Estimating the global incidence of traumatic brain injury. J. Neurosurg. 2019;130:1080–1097. doi: 10.3171/2017.10.JNS17352. - DOI - PubMed
    1. Agrawal A., Timothy J., Pandit L., Manju M. Post-traumatic epilepsy: An overview. Clin. Neurol. Neurosurg. 2006;108:433–439. doi: 10.1016/j.clineuro.2005.09.001. - DOI - PubMed
    1. Ding K., Gupta P.K., Diaz-Arrastia R. Epilepsy after Traumatic Brain Injury. In: Laskowitz D., Grant G., editors. Translational Research in Traumatic Brain Injury. CRC Press/Taylor and Francis Group; Boca Raton, FL, USA: 2016. Frontiers in Neuroscience.
    1. Annegers J.F., Hauser W.A., Coan S.P., Rocca W.A. A Population-Based Study of Seizures after Traumatic Brain Injuries. N. Engl. J. Med. 1998;338:20–24. doi: 10.1056/NEJM199801013380104. - DOI - PubMed
    1. Xu T., Yu X., Ou S., Liu X., Yuan J., Huang H., Yang J., He L., Chen Y. Risk factors for posttraumatic epilepsy: A systematic review and meta-analysis. Epilepsy Behav. 2017;67:1–6. doi: 10.1016/j.yebeh.2016.10.026. - DOI - PubMed

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