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Review
. 2019 Dec 19;12(1):20.
doi: 10.3390/cancers12010020.

Management of Liver Oligometastatic Esophageal Cancer: Overview and Critical Analysis of the Different Loco-Regional Treatments

Fabio Procopio  1 , Salvatore Marano  2 , Damiano Gentile  1 , Anna Da Roit  2 , Silvia Basato  2 , Pietro Riva  2 , Ferdinando De Vita  3 , Guido Torzilli  1 , Carlo Castoro  2
Affiliations
Review

Management of Liver Oligometastatic Esophageal Cancer: Overview and Critical Analysis of the Different Loco-Regional Treatments

Fabio Procopio et al. Cancers (Basel). .

Abstract

Esophageal cancer (EC) is an aggressive disease that is associated with a poor prognosis. Since metastastic EC is usually considered suitable only for palliative therapy with an estimated 5-year overall survival (OS) less than 5%, the optimal management of patients with liver oligometastatic EC (LOEC) is still undefined. The aim of this review is to provide an overview of the different treatment options for LOEC. A literature search was conducted using PubMed, Embase, and Cochrane to identify articles evaluating different treatment strategies for LOEC. Among 828 records that were identified, 20 articles met the inclusion criteria. These studies included patients who have undergone any type of surgical procedure and/or loco-regional therapy. Liver resection resulted in the best survival for patients with low tumor burden (3 lesions): 5-year OS 30-50% versus 8-12% after only chemotherapy (CHT). The 5-year OS of loco-regional therapies was 23% with a local recurrence risk ranging 0-8% for small lesions (2 to 3 cm). An aggressive multidisciplinary approach for LOEC patients may improve survival. Surgery seems to be the treatment of choice for resectable LOEC. If unfeasible, loco-regional therapies may be considered. In order to better select these patients and offer a chance of cure, prospective trials and a definition of treatment protocols are needed.

Keywords: esophageal cancer; liver oligometastatic esophageal cancer; noncolorectal nonneuroendocrine liver metastasis.

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Conflict of interest statement

The authors declared that they have no conflict of interest.

Figures

Figure 1
Figure 1
Diagram with a selection of studies for the review.
See this image and copyright information in PMC

References

    1. Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 2018;68:394–424. doi: 10.3322/caac.21492. - DOI - PubMed
    1. Noone A.M., Howlader N., Krapcho M., Miller D., Brest A., Yu M., Ruhl J., Tatalovich Z., Mariotto A., Lewis D.R., et al. National Cancer Institute; Bethesda, MD, USA: 2018. SEER Cancer Statistics Review, 1975–2015.
    1. Siegel R.L., Miller K.D., Jemal A. Cancer statistics. CA Cancer J. Clin. 2018;68:7–30. doi: 10.3322/caac.21442. - DOI - PubMed
    1. Ychou M., Boige V., Pignon J.P., Conroy T., Bouché O., Lebreton G., Ducourtieux M., Bedenne L., Fabre J.M., Saint-Aubert B., et al. Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: An FNCLCC and FFCD multicenter phase III trial. J. Clin. Oncol. 2011;29:1715–1721. doi: 10.1200/JCO.2010.33.0597. - DOI - PubMed
    1. Kutup A., Nentwich M.F., Bollschweiler E., Bogoevski D., Izbicki J.R., Hölscher A.H. What should be the gold standard for the surgical component in the treatment of locally advanced esophageal cancer: Transthoracic versus transhiatal esophagectomy. Ann. Surg. 2014;260:1016–1022. doi: 10.1097/SLA.0000000000000335. - DOI - PubMed

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