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Review
. 2020 Feb 15:591:113543.
doi: 10.1016/j.ab.2019.113543. Epub 2019 Dec 17.

An overview of sulfur-containing compounds originating from natural metabolites: Lanthionine ketimine and its analogues

Dunxin Shen  1 , Kenneth Hensley  2 , Travis T Denton  3
Affiliations
Review

An overview of sulfur-containing compounds originating from natural metabolites: Lanthionine ketimine and its analogues

Dunxin Shen et al. Anal Biochem. .

Abstract

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Conflict of interest statement

Declaration of competing interest Dr. Hensley is the inventor on the patent titled: LANTHIONINE-RELATED COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISEASES, Publication number: 20070197515. Drs. Hensley and Denton are inventors on the patent titled: COMPOSITIONS USEFUL IN THERAPY OF AUTOPHAGY-RELATED PATHOLOGIES, AND METHODS OF MAKING AND USING THE SAME, Publication number: 20190040091.

Figures

Figure 1.
Figure 1.
The imine and enamine forms of LK
Figure 2.
Figure 2.
Formation of sulfur-containing cyclic ketimines sharing the same metabolic pathway; CβS - cystathionine-β-synthase; GTK - glutamine transaminase K (Modified from K. Hensley, T.T. Denton, Alternative functions of the brain transsulfuration pathway represent an underappreciated aspect of brain redox biochemistry with significant potential for therapeutic engagement [31])
Figure 3.
Figure 3.
Synthesized LK phosphonate analogues [13]. The phosphonic acid residue affords a highly hydrophilic group, which is balanced by the inclusion of hydrophobic groups at the 2-position and the ethyl ester group
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