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Review
. 2020 Apr 20:99:109847.
doi: 10.1016/j.pnpbp.2019.109847. Epub 2019 Dec 17.

Common neurobiological and psychological underpinnings of gambling and substance-use disorders

Iris M Balodis  1 , Marc N Potenza  2
Affiliations
Review

Common neurobiological and psychological underpinnings of gambling and substance-use disorders

Iris M Balodis et al. Prog Neuropsychopharmacol Biol Psychiatry. .

Abstract

Both psychological and neurobiological studies in gambling disorder have increased in the past 10-15 years. This review examines the current state of the literature, with a focus on recent magnetic resonance imaging (MRI) studies in gambling disorder. The review compares and contrasts findings across gambling and substance-use disorders. Additionally, features with arguably particular relevance to gambling disorder (e.g., "near-miss" processing) are described, as well as their relationship to choice behaviors. More broadly, the review informs on how these studies advance our understanding of brain-behavior relationships relating to decision-making and key features of addictive disorders.

Keywords: Addiction; Gambling; Near-miss; Striatum; rTMS.

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Conflict of interest statement

Declaration of Competing Interest The authors have no pertinent disclosures or conflict of interest. Over the past three years, Dr. Potenza has received financial support (to Yale or personally) for the following. He has consulted for and advised Game Day Data, Addiction Policy Forum, and Opiant Therapeutics; received research support from the Mohegan Sun Casino and the National Center for Responsible Gaming; consulted for or advised legal and gambling entities on issues related to impulse control and addictive behaviors; provided clinical care related to impulse-control and addictive behaviors; performed grant reviews; edited journals/journal sections; given academic lectures in grand rounds, CME events and other clinical/scientific venues; and generated books or chapters for publishers of mental health texts. Dr. Balodis reports no disclosures.

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