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. 2019 Dec 20;9(1):19595.
doi: 10.1038/s41598-019-56102-w.

Association between health related quality of life and progression of chronic kidney disease

Tae Ryom Oh  1 , Hong Sang Choi  1 , Chang Seong Kim  1 , Eun Hui Bae  1 , Yun Kyu Oh  2 , Yong-Soo Kim  3 , Kyu Hun Choi  4 , Soo Wan Kim  5 , Seong Kwon Ma  6
Affiliations

Association between health related quality of life and progression of chronic kidney disease

Tae Ryom Oh et al. Sci Rep. .

Abstract

The impact of health-related quality of life (HRQOL) on outcomes remains unclear in chronic kidney disease (CKD) patients despite its importance in socioeconomic aspects and individual health. We aim to identify the relationship between HRQOL and progression of CKD in pre-dialysis patients. A total 1622 patients with CKD were analyzed in the KoreaN cohort Study for Outcomes in patients With Chronic Kidney Disease, a prospective cohort study. CKD progression was defined as one or more of the following: initiation of dialysis or transplantation, a two-fold increase in baseline serum creatinine levels, or a 50% decline in the estimated glomerular filtration rate during the follow-up period. The group with CKD progression had lower scores of HRQOL than the group without CKD progression. A fully adjusted Cox proportional hazard ratio model showed that each low baseline physical and mental component summary score was associated with a higher risk of CKD progression. In Kaplan-Meier survival analysis using propensity score matched data, only low physical component summary scores showed statistical significance with CKD progression. Our study highlights low physical component summary score for an important prognostic factor of CKD progression. Risk-modification interventions for high-risk patients may provide benefits to individuals.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Distribution of the HRQOL scores according to CKD stages. (A) Scores for physical component summary and related subscales. (B) Scores for mental component summary and related subscales. Abbreviation: CKD, chronic kidney disease; HRQOL, health-related quality of life.
Figure 2
Figure 2
Restricted cubic spline curve for the Cox proportional hazard model of HRQOL. (A) A linear relationship between the renal outcome and PCS score was observed. (B) A non-linear relationship between the renal outcome and MCS score was observed. Abbreviation: HRQOL, health-related quality of life; MCS, mental component summary; PCS, physical component summary.
Figure 3
Figure 3
Difference in survival probability between control and low HRQOL group with propensity score matching. (A) Kaplan-Meier survival curve for low PCS group. (B) Kaplan-Meier survival curve for low MCS group. Abbreviation: HRQOL, health-related quality of life; MCS, mental component summary; PCS, physical component summary.
Figure 4
Figure 4
Subgroup analysis for the association between low PCS and CKD progression. Low PCS was a consistent risk factor for CKD progression in all subgroups. Abbreviation: CKD, chronic kidney disease; HRQOL, health-related quality of life; PCS, physical component summary.
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References

    1. Kim KM, Oh HJ, Choi HY, Lee H, Ryu DR. Impact of chronic kidney disease on mortality: A nationwide cohort study. Kidney research and clinical practice. 2019;38:382–390. doi: 10.23876/j.krcp.18.0128. - DOI - PMC - PubMed
    1. Korea Centers for Disease Control and Prevention. Prevalence of Chronic Kidney Disease in Korea (2013).
    1. Korea Centers for Disease Control and Prevention. The Socioeconomic Cost of Chronic Kidney Disease (2012).
    1. Hunsicker LG. The consequences and costs of chronic kidney disease before ESRD. Journal of the American Society of Nephrology: JASN. 2004;15:1363–1364. doi: 10.1097/01.ASN.0000126069.68755.99. - DOI - PubMed
    1. Chadban SJ, et al. Prevalence of kidney damage in Australian adults: The AusDiab kidney study. Journal of the American Society of Nephrology: JASN. 2003;14:S131–138. doi: 10.1097/01.ASN.0000070152.11927.4A. - DOI - PubMed

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