Targeting pyrimidine metabolism for glioblastoma therapy

Affiliations

¹ Departments of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
² Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Comment

Veerakumar Balasubramaniyan et al. Neuro Oncol. 2020.

. 2020 Feb 20;22(2):169-170.

doi: 10.1093/neuonc/noz239.

¹ Departments of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
² Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

No abstract available

Comment on

Discovery of a new pyrimidine synthesis inhibitor eradicating glioblastoma-initiating cells.
Echizenya S, Ishii Y, Kitazawa S, Tanaka T, Matsuda S, Watanabe E, Umekawa M, Terasaka S, Houkin K, Hatta T, Natsume T, Maeda Y, Watanabe SI, Hagiwara S, Kondo T. Echizenya S, et al. Neuro Oncol. 2020 Feb 20;22(2):229-239. doi: 10.1093/neuonc/noz170. Neuro Oncol. 2020. PMID: 31499527 Free PMC article.

1. Tirosh I, Suvà ML. Dissecting human gliomas by single-cell RNA sequencing. Neuro Oncol. 2018;20(1):37–43. - PMC - PubMed
1. Echizenya S, Ishii Y, Kitazawa S, et al. . Discovery of a new pyrimidine synthesis inhibitor eradicating glioblastoma-initiating cells. Neuro Oncol. 2019. doi:10.1093/neuonc/noz170. - DOI - PMC - PubMed
1. Bajzikova M, Kovarova J, Coelho AR, et al. . Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells. Cell Metab. 2019;29(2):399–416.e10. - PMC - PubMed
1. Wang X, Yang K, Wu Q, et al. . Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells. Sci Transl Med. 2019;11. - PMC - PubMed
1. White RM, Cech J, Ratanasirintrawoot S, et al. . DHODH modulates transcriptional elongation in the neural crest and melanoma. Nature. 2011;471(7339):518–522. - PMC - PubMed