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Review
. 2020 Feb;87(2):125-131.
doi: 10.1007/s12098-019-03123-y. Epub 2019 Dec 21.

Pediatric Blood Cultures and Antibiotic Resistance: An Overview

Chand Wattal  1 , Neeraj Goel  2
Affiliations
Review

Pediatric Blood Cultures and Antibiotic Resistance: An Overview

Chand Wattal et al. Indian J Pediatr. 2020 Feb.

Erratum in

Abstract

Bloodstream infections (BSI) due to multidrug-resistant organisms, especially from pediatric intensive care units (PICU), are being increasingly reported across the world. Since BSI is associated with high mortality, it is essential to treat these infections early with appropriate antibiotics. Surveillance of etiology and emerging antimicrobial resistance (AMR) is considered an important step in the formulation of antibiotic policy for early treatment and judicious use of antibiotics. In this review on etiology and its antibiogram in community acquired BSI, S. typhi followed by S. paratyphi A were the major bacterial isolates. Quinolone resistance of more than 90% in Salmonella is now reported from all over India. Ceftriaxone remains the drug of choice for enteric fever due to its 100% susceptibility. In PICU there is an emergence of candidemia due to non-albicans candida which are now predominant isolates at few centers. BSI due to gram-negative bacteria, mostly by Klebseilla pneumoniae and gram-positive cocci (S. aureus) are the other major pathogens commonly observed in BSI from PICU. There is a high prevalence of antimicrobial resistance to commonly used antibiotics like ampicillin (94.9%-90.7%), cefotaxime (92.4%-71.4%), piperacillin-tazobactum (31.2%-27.5%) and levofloxacin (42.4%-39.8%). Resistance to carbapenems, primarily due to blaNDM is seen in all the centers and the rate varies between 1%- 79% with K. pneumoniae and A. baumannii showing the maximum resistance. This review highlights the magnitude of the AMR in the pediatric population and calls for the urgent implementation of antimicrobial stewardship programs to save the remaining antimicrobials.

Keywords: AMR; Etiology; PICU; Pediatric blood culture; Surveillance.

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Conflict of interest statement

None.

Figures

Fig. 1
Fig. 1
Etiology of BSI in pediatric age group in OPD samples (2014–2018)
Fig. 2
Fig. 2
Isolates of BSI in Pediatric ICU (2014–2018)
Fig. 3
Fig. 3
Various species of Candida isolated in BSI from PICU (2014–2018)
See this image and copyright information in PMC

Comment in

References

    1. Falagas ME, Tansarli GS, Karageorgopoulos DE, Vardakas KZ. Deaths attributable to carbapenem-resistant Enterobacteriaceae infections. Emerg Infect Dis. 2014;20:1170–1175. doi: 10.3201/eid2007.121004. - DOI - PMC - PubMed
    1. Gray JW. A 7-year study of bloodstream infections in an English children's hospital. Eur J Pediatr. 2004;163:530–535. doi: 10.1007/s00431-004-1489-7. - DOI - PubMed
    1. Stoll BJ, Hansen N, Fanaroff AA, et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics. 2002;110:285–291. doi: 10.1542/peds.110.2.285. - DOI - PubMed
    1. Posfay-Barbe KM, Zerr DM, Pittet D. Infection control in paediatrics. Lancet Infect Dis. 2008;8:19–31. doi: 10.1016/S1473-3099(07)70310-9. - DOI - PubMed
    1. Wattal C, Oberoi J. Infections in pediatric intensive care units (PICU) Indian J Pediatr. 2012;79:647–649. doi: 10.1007/s12098-012-0696-x. - DOI - PubMed

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