Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Dec;177(23):5270-5286.
doi: 10.1111/bph.14951. Epub 2020 Feb 3.

Ageing, sex, and cardioprotection

Marisol Ruiz-Meana  1   2 , Kerstin Boengler  3 , David Garcia-Dorado  1   2 , Derek J Hausenloy  4   5   6   7   8   9 , Tuuli Kaambre  10 , Georgios Kararigas  11   12 , Cinzia Perrino  13 , Rainer Schulz  3 , Kirsti Ytrehus  14
Affiliations
Review

Ageing, sex, and cardioprotection

Marisol Ruiz-Meana et al. Br J Pharmacol. 2020 Dec.

Abstract

Translation of cardioprotective interventions aimed at reducing myocardial injury during ischaemia-reperfusion from experimental studies to clinical practice is an important yet unmet need in cardiovascular medicine. One particular challenge facing translation is the existence of demographic and clinical factors that influence the pathophysiology of ischaemia-reperfusion injury of the heart and the effects of treatments aimed at preventing it. Among these factors, age and sex are prominent and have a recognised role in the susceptibility and outcome of ischaemic heart disease. Remarkably, some of the most powerful cardioprotective strategies proven to be effective in young animals become ineffective during ageing. This article reviews the mechanisms and implications of the modulatory effects of ageing and sex on myocardial ischaemia-reperfusion injury and their potential effects on cardioprotective interventions. LINKED ARTICLES: This article is part of a themed issue on Risk factors, comorbidities, and comedications in cardioprotection. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.23/issuetoc.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Molecular players involved in the mitochondrial cardioprotective response during IR that may be altered in aged cardiomyocytes. Supercomplex mitochondrial interactosome (MIt), consisting of mitochondrial ATP synthase, phosphate carrier (PiC), voltage‐dependent anion channel (VDAC), mitochondrial creatine kinase (MtCK), adenine nucleotide translocator (ANT), and respiratory chain complexes, is shown separately. AK, adenylate kinase; HK, hexokinase; IMS, intermembrane space; MIM, mitochondrial inner membrane; MOM, mitochondrial outer membranes; SR, sarcoplasmic reticulum
FIGURE 2
FIGURE 2
Intracellular targets altered by ageing and sex that can be targeted by specific cardioprotective strategies
FIGURE 3
FIGURE 3
Multitarget strategies involved in cardioprotection. Multiple cardiac and extra‐cardiac factors modulate IR injury in the heart and are potentially targetable by cardioprotective interventions
See this image and copyright information in PMC

References

    1. Adam, T. , Sharp, S. , Opie, L. H. , & Lecour, S. (2013). Loss of cardioprotection with ischemic preconditioning in aging hearts: Role of sirtuin 1? Journal of Cardiovascular Pharmacology and Therapeutics, 18, 46–53. - PubMed
    1. Agarwal, B. , Dash, R. K. , Stowe, D. F. , Bosnjak, Z. J. , & Camara, A. K. (2014). Isoflurane modulates cardiac mitochondrial bioenergetics by selectively attenuating respiratory complexes. Biochimica et Biophysica Acta, 1837, 354–365. 10.1016/j.bbabio.2013.11.006 - DOI - PMC - PubMed
    1. Alexander, S. P. H. , Christopoulos, A. , Davenport, A. P. , Kelly, E. , Mathie, A. , Peters, J. A. , … CGTP Collaborators (2019). The Concise Guide to PHARMACOLOGY 2019/20: G protein‐coupled receptors. British Journal of Pharmacology, 176, S21–S141. 10.1111/bph.14748 - DOI - PMC - PubMed
    1. Alexander, S. P. H. , Cidlowski, J. A. , Kelly, E. , Mathie, A. , Peters, J. A. , Veale, E. L. , … CGTP Collaborators (2019). The Concise Guide to PHARMACOLOGY 2019/20: Nuclear hormone receptors. British Journal of Pharmacology, 176, S229–S246. 10.1111/bph.14750 - DOI - PMC - PubMed
    1. Alexander, S. P. H. , Fabbro, D. , Kelly, E. , Mathie, A. , Peters, J. A. , Veale, E. L. , … CGTP Collaborators (2019). The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. British Journal of Pharmacology, 176, S297–S396. 10.1111/bph.14752 - DOI - PMC - PubMed

Publication types

Substances