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. 2020 Jan;33(1):e13190.
doi: 10.1111/dth.13190. Epub 2020 Jan 2.

Targeting interleukin 4 receptor α: A new approach to the treatment of cutaneous autoimmune bullous diseases?

Roberto Russo  1   2 , Emanuele Cozzani  1   2 , Giulia Gasparini  1   2 , Aurora Parodi  1   2
Affiliations

Targeting interleukin 4 receptor α: A new approach to the treatment of cutaneous autoimmune bullous diseases?

Roberto Russo et al. Dermatol Ther. 2020 Jan.

Abstract

Bullous pemphigoid, mucous membrane pemphigoid, and pemphigus vulgaris are different cutaneous autoimmune blistering diseases, with complex pathogenic mechanisms. In all of them, a type-2 response is thought to have a central role. Interleukin 4 and Interleukin 13 are crucial cytokines in type-2 response. Treatment of these conditions is often challenging. Dupilumab, a recombinant fully human IgG4 monoclonal antibody with binding specificity to human interleukin-4 receptor IL-4Rα, has the potential to inhibit both IL-4 and IL-13. We propose IL-4Rα as a theoretical drug target for cutaneous autoimmune bullous diseases.

Keywords: blistering diseases; bullous pemphigoid; dupilumab; mucous membrane pemphigoid; pemphigus vulgaris.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Role of Interleukin 4 (IL‐4) and Interleukin 13 (IL‐13) in pathogenesis of bullous pemphigoid (BP), mucous membrane pemphigoid (MMP), and pemphigus vulgaris (PV). Interleukin 4 and Interleukin 13 activities would be opposed by dupilumab
See this image and copyright information in PMC

References

    1. Aoudjehane, L. , Pissaia, A., Jr. , Scatton, O. , Podevin, P. , Massault, P. P. , Chouzenoux, S. , … Conti, F. (2008). Interleukin‐4 induces the activation and collagen production of cultured human intrahepatic fibroblasts via the stat‐6 pathway. Laboratory Investigation, 88, 973–985. - PubMed
    1. Bailey, J. R. , Bland, P. W. , Tarlton, J. F. , Peters, I. , Moorghen, M. , Sylvester, P. A. , … Whiting, C. V. (2012). IL‐13 promotes collagen accumulation in Crohn's disease fibrosis by down‐regulation of fibroblast MMP synthesis: A role for innate lymphoid cells? PLoS One, 7, e52332. - PMC - PubMed
    1. Bellini, A. , Marini, M. A. , Bianchetti, L. , Barczyk, M. , Schmidt, M. , & Mattoli, S. (2012). Interleukin (IL)‐4, IL‐13, and IL‐17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients. Mucosal Immunology, 5, 140–149. - PubMed
    1. Belperio, J. A. , Dy, M. , Burdick, M. D. , Xue, Y. Y. , Li, K. , Elias, J. A. , & Keane, M. P. (2002). Interaction of IL‐13 and C10 in the pathogenesis of bleomycin‐induced pulmonary fibrosis. American Journal of Respiratory Cell and Molecular Biology, 27, 419–427. - PubMed
    1. Bernard, P. , & Antonicelli, F. (2017). Bullous pemphigoid: A review of its diagnosis, associations and treatment. American Journal of Clinical Dermatology, 18, 513–528. - PubMed

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