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Review
. 2020 Apr;1867(4):118627.
doi: 10.1016/j.bbamcr.2019.118627. Epub 2019 Dec 19.

Multifaceted roles of COPII subunits in autophagy

Zhongyu Li  1 , Wei Huang  1 , Wei Wang  2
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Free article
Review

Multifaceted roles of COPII subunits in autophagy

Zhongyu Li et al. Biochim Biophys Acta Mol Cell Res. 2020 Apr.
Free article

Abstract

COPII vesicles mediate anterograde ER-Golgi traffic of newly synthesized proteins in nutrient rich conditions. An accumulating body of results indicates that the secretory COPII vesicles can be shifted to the roles in autophagosome formation and selective ER-phagy (autophagy of ER), depending on their specific subunits, in response to environmental stresses. In this mini-review, we summarize and discuss the multifaceted roles of COPII vesicles in autophagy and the underlying molecular mechanisms.

Keywords: Autophagy; COPII; ER-Golgi traffic; ER-phagy.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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