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. 1978 Sep 15;174(3):1055-8.
doi: 10.1042/bj1741055.

Regulation of monkey liver serine hydroxymethyltransferase by nicotinamide nucleotide

K S Ramesh, N A Rao

Regulation of monkey liver serine hydroxymethyltransferase by nicotinamide nucleotide

K S Ramesh et al. Biochem J. .

Abstract

The positive homotropic binding of tetrahydrofolate to monkey liver serine hydroxymethyltransferase was abolished on preincubating the enzyme with NADH and NADPH. NAD+ was a negative heterotropic effector, whereas NADP+ was without effect. The allosteric effects of nicotinamide nucleotides on the serine hydroxymethyltransferase, reported for the first time, lead to a better understanding of the regulation of the metabolic interconversion of folate coenzymes.

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