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. 1978 Sep 15;174(3):1055-8.
doi: 10.1042/bj1741055.

Regulation of monkey liver serine hydroxymethyltransferase by nicotinamide nucleotide

K S Ramesh, N A Rao

Regulation of monkey liver serine hydroxymethyltransferase by nicotinamide nucleotide

K S Ramesh et al. Biochem J. .

Abstract

The positive homotropic binding of tetrahydrofolate to monkey liver serine hydroxymethyltransferase was abolished on preincubating the enzyme with NADH and NADPH. NAD+ was a negative heterotropic effector, whereas NADP+ was without effect. The allosteric effects of nicotinamide nucleotides on the serine hydroxymethyltransferase, reported for the first time, lead to a better understanding of the regulation of the metabolic interconversion of folate coenzymes.

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References

    1. Proc Natl Acad Sci U S A. 1976 Jun;73(6):1950-3 - PubMed
    1. Biochem J. 1975 Feb;145(2):159-68 - PubMed
    1. J Biol Chem. 1962 Oct;237:3299-302 - PubMed
    1. J Biol Chem. 1951 Nov;193(1):265-75 - PubMed
    1. Biochim Biophys Acta. 1971 Dec 15;250(3):459-77 - PubMed