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. 2019 Dec 21;19(1):264.
doi: 10.1186/s12886-019-1265-0.

Risk factors for glial cell proliferation after idiopathic macular hole repair with internal limiting membrane flap

Yuyan Liu  1 , Changlong Wu  2 , Ying Wang  1 , Yi Dong  1 , Dongqing Liang  1 , Bo Xiao  1 , Quanhong Han  1 , Yanhua Chu  3
Affiliations

Risk factors for glial cell proliferation after idiopathic macular hole repair with internal limiting membrane flap

Yuyan Liu et al. BMC Ophthalmol. .

Abstract

Background: To study the influencing factors for different healing patterns of patients with idiopathic macular holes (IMH) after vitrectomy surgery performed with the internal limiting membrane (ILM) flap technique.

Methods: This study was a retrospective, consecutive, observational case series study. We recruited 52 IMH patients who underwent vitrectomy with the ILM flap technique. The participants were divided into 2 groups: group A (25 patients), without significant glial cell proliferation in the macular area on postoperative optical coherence tomography (OCT); and group B (27 patients), with significant glial cell proliferation. The postoperative visual acuity (VA), external limiting membrane (ELM) and ellipsoid zone (EZ) recovery characteristics were compared between the two groups.

Results: There were statistically significant differences in minimum linear diameter (MLD) of the macular hole and postoperative VA (p = 0.02, 2.81 E-4 respectively) between the two groups. Compared with patients in group A, patients in group B had poorer VA and EZ recovery in the first 12 months after surgery, and a longer ELM recovery period. The OCT results showed that patients in group B had more extensive ILM filling in the macular area after surgery than patients in group A.

Conclusion: The presence of aberrant glial cell proliferation was related to a larger MLD of the IMH, and the filling approach for the ILM during the operation was related to the postoperative healing pattern and vision acuity.

Keywords: Glial cell proliferation; Idiopathic macular hole; Internal limiting membrane flap; Optical coherence tomography; Vitrectomy.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Examples of the preoperative measurement of the macular hole. This image is a horizontal scan of the OCT results through the macular fovea
Fig. 2
Fig. 2
Preoperative and postoperative visual acuity changes of the two groups at different times
Fig. 3
Fig. 3
The variation trend of the lengths of the ELM (a) and EZ (b) discontinuity in the macular area in the two groups at different times post operation
Fig. 4
Fig. 4
Visual acuity and OCT results pre and post operation of a patient from group A were shown in column a, and the results of a patient from group B were shown in column b. The proliferation of glial cells were shown with arrows in column b
Fig. 5
Fig. 5
Visual acuity and OCT results before and after operation were observed in the two groups. The results of a patient from group A were shown in column a, and the results of three patients from group b were shown in column b, column c and column d, respectively. The patient of column c had a deeper filling depth (shown with arrows) of the ILM during the operation than which of the patient of column d
See this image and copyright information in PMC

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