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Comment
. 2020 Jan;140(1):13-14.
doi: 10.1016/j.jid.2019.07.678.

IL-17A Softens the Skin: Antifibrotic Properties of IL-17A in Systemic Sclerosis

Chang Zeng  1 , J Michelle Kahlenberg  2 , Johann E Gudjonsson  3
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Comment

IL-17A Softens the Skin: Antifibrotic Properties of IL-17A in Systemic Sclerosis

Chang Zeng et al. J Invest Dermatol. 2020 Jan.
Free article

Abstract

IL-17A is abundant in scleroderma skin, but its pathologic role has remained unclear. In the Journal of Investigative Dermatology, Dufour et al. (2020) demonstrate a new role for IL-17A as an antifibrotic agent in scleroderma through modulation of keratinocyte responses to transforming growth factor-β and shifting of fibroblast responses from profibrotic to antifibrotic.

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