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Review
. 2020 Mar:127:154953.
doi: 10.1016/j.cyto.2019.154953. Epub 2019 Dec 19.

Chemokines in human obesity

Volatiana Rakotoarivelo  1 , Bhavesh Variya  1 , Marie-France Langlois  2 , Sheela Ramanathan  1
Affiliations
Review

Chemokines in human obesity

Volatiana Rakotoarivelo et al. Cytokine. 2020 Mar.

Abstract

Obesity and type 2 diabetes have been shown to be associated with chronic inflammation. Despite extensive evidence for inflammatory mediators in the obese patients and multiple clinical trials, the outcome has been disappointing. In murine models recruitment of immune cells during inflammation has been shown to contribute to the chronic inflammation. Clearcut evidence for the differential expression of chemokines that mediate this recruitment is not available. In this short review we discuss the observations on CCL2 and CCL5 in human obesity.

Keywords: Chemokines; Human obesity; Subcutaneous adipose tissues; Visceral adipose tissues.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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